Dimethylamine
Athanor · official
C2H7N · 45.08 g/mol
IUPAC name: N-methylmethanamine
Also called DMA, N-methylmethanamine
Names and identifiers
- IUPAC name
- N-methylmethanamine
- Synonyms
- DMA, N-methylmethanamine, N-Methylmethanamine
+ 36 more
N,N-Dimethylamine, Methanamine, N-methyl-, Dimethylamine (anhydrous), RCRA waste number U092, DTXSID5024057, Ai3-15638-X, ARQ8157E0Q, Dimethylamine, anhydrous, NSC-8650, DTXCID704057, CHEBI:17170, methanamine, N-methyl, RefChem:5765, 204-697-4, Dimethylamine anhydrous, DIMETHYLAMINE-N-D1, (CH3)2NH, Dimethylamine aq, NSC 8650, HNMe2, Me2NH, MFCD00008288, Dimethylamine (40% aq.), Dimethylamine (~2.0 M in THF), Dimethylamine, 40% aqueous solution, dimethyl amine, dimethyl-amine, Dimethylamine solution purum 33% in absolute ethanol (~5.6 M), CCRIS 981, HSDB 933, Dimethylamine Hydrochloride-13C2, EINECS 204-697-4, UN1032, UN1160, RCRA waste no. U092, dimethlamine
- Molecular formula
- C2H7N
- Empirical formula
- C2H7N
- Molecular weight
- 45.08 g/mol
- Exact mass
- 45.05785
- CAS number
- 124-40-3
- PubChem CID
- 674
- Canonical SMILES
- CNC
- Isomeric SMILES
- CNC
- InChI
- InChI=1S/C2H7N/c1-3-2/h3H,1-2H3
- InChIKey
- ROSDSFDQCJNGOL-UHFFFAOYSA-N
- Molfile
Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.
Physical properties
- Appearance
- Colorless gas[6]
8 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source – Dimethylamine, anhydrous appears as a colorless gas smelling of fish at low concentrations and of ammonia at higher concentrations. Shipped as a liquid under its vapor pressure. Contact with the unconfined liquid can cause frostbite by evaporative cooling and chemical type burns. The gas, which is corrosive, dissolves readily in water to form flammable corrosive solutions. The gas is heavier than air and can asphyxiate by the displacement of air. Gas is easily ignited and produces toxic oxides of nitrogen when burned. Long-term inhalation of low concentrations or short-term inhalation of low c [1] CAMEO Chemicals – Dimethylamine, aqueous solution appears as a solution of a gas in water. Odor ranging from a fishlike to ammonia-like depending on vapor concentration. Corrosive to skin and eyes. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. [1] CAMEO Chemicals – Gas Vapor; Liquid; Liquid [2] EPA Chemical Data Reporting (CDR) – COLOURLESS COMPRESSED LIQUEFIED GAS WITH PUNGENT ODOUR. [3] ILO-WHO International Chemical Safety Cards (ICSCs) – SOLUTION IN WATER WITH PUNGENT ODOUR. [3] ILO-WHO International Chemical Safety Cards (ICSCs) – Colorless gas with an ammonia- or fish-like odor. [4] Occupational Safety and Health Administration (OSHA) – Colorless gas with an ammonia- or fish-like odor. [Note: A liquid below 44 °F. Shipped as a liquefied compressed gas.] [5] The National Institute for Occupational Safety and Health (NIOSH) –shown Colorless gas [6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg - Odor
- ... Ammonia or fish-like odor ...[6]
- Melting point
- -92.18 °C[7]
6 values
5 of 5 sources agree on it (most common value).
Value As written Source −93 °C -135 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. −92.2 °C -92.2 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) −37 °C -37 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) −92 °C -134 °F [4] Occupational Safety and Health Administration (OSHA) −92.2 °Cshown -92.18 °C [7] PAC Chemical Database, U.S. Department of Energy −92 °C -134 °F [5] The National Institute for Occupational Safety and Health (NIOSH) - Boiling point
- 6.88 °C @760 [mmHg][7]
6 values
5 of 5 sources agree on it (most common value).
Value As written Source 7.4 °C 45.3 °F at 760 mmHg (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. 7.0 °C 7.0 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) 51 °C 51 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) 7 °C 44 °F [4] Occupational Safety and Health Administration (OSHA) 6.9 °Cshown 6.88 °C @760 [mm Hg] [7] PAC Chemical Database, U.S. Department of Energy 7 °C 44 °F [5] The National Institute for Occupational Safety and Health (NIOSH) - Density
- 0.6804 @ 0°C[7]
7 values
5 of 5 sources agree on it (most common value).
Value As written Source – 0.671 at 44.4 °F (USCG, 1999) - Less dense than water [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office. – Relative density (water = 1): 0.7 [3] ILO-WHO International Chemical Safety Cards (ICSCs) – Relative density (water = 1): 0.9 [3] ILO-WHO International Chemical Safety Cards (ICSCs) – 0.67 (liquid at 44 °F) [4] Occupational Safety and Health Administration (OSHA) –shown 0.6804 @ 0°C [7] PAC Chemical Database, U.S. Department of Energy – 0.67 (Liquid at 44 °F) [5] The National Institute for Occupational Safety and Health (NIOSH) – 1.56(relative gas density) [5] The National Institute for Occupational Safety and Health (NIOSH) 6 more values were reported but failed the checks (unreadable or out of range), so they are not shown.
- Solubility in water
- Solubility in water: very soluble[3]
5 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source – 24 % at 140 °F (NIOSH, 2024) [1] CAMEO Chemicals – In water, 163 g/100g water at 40 °C [6] Hazardous Substances Data Bank (HSDB)cites Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V2: 371 (1992) – Solubility in water, g/100ml: 354 (very soluble) [3] ILO-WHO International Chemical Safety Cards (ICSCs) –shown Solubility in water: very soluble [3] ILO-WHO International Chemical Safety Cards (ICSCs) – (140 °F): 24% [5] The National Institute for Occupational Safety and Health (NIOSH) - log P
- -0.38[3]
3 values
2 of 2 sources agree on it (most common value).
Value As written Source – log Kow = -0.38 [6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 5 – -0.2 [3] ILO-WHO International Chemical Safety Cards (ICSCs) –shown -0.38 [3] ILO-WHO International Chemical Safety Cards (ICSCs) - pKa
- pKa = 10.732 at 25 °C (conjugate acid)[6]
- Vapor pressure
- 1520 mmHg at 25 °C[6]
5 values
2 of 4 sources agree on it (most common value).
Value As written Source 1388.03 mmHg 1388.03 mmHg at 70 °F (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office. 1520 mmHgshown 1520 mm Hg at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Daubert, T.E., R.P. Danner. Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, D.C.: Taylor and Francis, 1989. 1500 mmHg Vapor pressure, kPa at 25 °C: 203 [3] ILO-WHO International Chemical Safety Cards (ICSCs) 200 mmHg Vapor pressure, kPa at 20 °C: 26.3 [3] ILO-WHO International Chemical Safety Cards (ICSCs) 750 mmHg 750 [mm Hg] @6.6 °C [7] PAC Chemical Database, U.S. Department of Energy 2 more values were reported but failed the checks (unreadable or out of range), so they are not shown.
- Flash point
- -6.69 °C (19.96 °F) - closed cup[6]
5 values
3 of 4 sources agree on it (most common value).
Value As written Source −7 °C 20 °F (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office. −6.7 °Cshown -6.69 °C (19.96 °F) - closed cup [6] Hazardous Substances Data Bank (HSDB)cites Sigma-Aldrich; Safety Data Sheet for Dimethylamine, Product Number: 295280, Version 4.7 (Revision Date 10/04/2018). Available from, as of January 14, 2019: https://www.sigmaaldrich.com/safety-center.html −7 °C 20 °F (Closed cup) [6] Hazardous Substances Data Bank (HSDB)cites U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5. −18 °C -18 °C c.c. [3] ILO-WHO International Chemical Safety Cards (ICSCs) −7 °C 20 °F (liquid) [4] Occupational Safety and Health Administration (OSHA) 1 more value was reported but failed the checks (unreadable or out of range), so it is not shown.
- Autoignition temperature
- 400 °C[3]
4 values
2 of 3 sources agree on it (most common value).
Value As written Source 402 °C 756 °F (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office. 400 °C 752 °F (400 °C) [6] Hazardous Substances Data Bank (HSDB)cites National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14TH Edition, Quincy, MA 2010, p. 325-49 400 °Cshown 400 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) 400 °C 400 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) - Viscosity
- 1.7 mPa*s at 20 °C[3]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source – 1.7 mPa.s at 15.5 °C /40% Dimethylamine aqueous solution/ [6] Hazardous Substances Data Bank (HSDB)cites Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present., p. VA16: 536 (1990) –shown 1.7 mPa*s at 20 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.
Calculated
- Heavy atoms
- 3
- Rings
- 0
- Aromatic rings
- 0
- Fraction sp³ carbons (Fsp3)
- 1
- H-bond donors
- 1
- H-bond acceptors
- 1
- Rotatable bonds
- 0
- TPSA (Ų)
- 12
- Formal charge
- 0
- XLogP3
- -0.2 PubChem
- Complexity
- 2 PubChem
- Stereocenters
- None
- Double-bond geometry
- None specified
- Point group
- Cs of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)
Elemental analysis
- C53.28%
- H15.65%
- N31.07%
Isotope pattern
Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.
Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.
Predicted
- log P
- -0.16 Crippen (Wildman and Crippen 1999)
- log S (water solubility)
- -0.02 ESOL (Delaney 2004), log mol/L
- Synthetic accessibility
- 2.22 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)
Drug-likeness: Lipinski’s rule of five
- Molecular weight ≤ 500: 45.09
- log P ≤ 5 (Crippen): -0.16
- H-bond donors ≤ 5: 1
- H-bond acceptors ≤ 10: 1
Passes all four rules.
¹³C NMR shifts, predicted
Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.
Safety
Danger
Harmonized EU classification (CLP Annex VI). Source [8].
Flammable
Compressed gas
Corrosive
Harmful or irritant
- H220Extremely flammable gas
- H315Causes skin irritation
- H318Causes serious eye damage
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements: P203, P210, P222, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P377, P381, P403, P403+P233, P405, P501
View all classifications (4)
- [8] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH220, H315, H318, H332, H335
- [8] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH224, H302, H314, H332
- [9] European Chemicals Agency (ECHA) · 3,043 reports · DangerH220, H224, H280, H302, H314, H315, H318, H332, H335, H411, H412
- [6] Hazardous Substances Data Bank (HSDB) · DangerH220, H280, H315, H318, H332, H335, H402, H412
Exposure limits
- PEL-TWA (8-Hour Time Weighted Average): 10 ppm (18 mg/m³)[4]
- PEL: TWA 10 ppm (18 mg/m3)[5]
- TLV: 5 ppm as TWA; 15 ppm as STEL; (DSEN); A4 (not classifiable as a human carcinogen).[3]
- TLV-TWA (Time Weighted Average): 5 ppm [2013][4]
- TLV-STEL (Short Term Exposure Limit): 15 ppm [2013][4]
- IDLH: 500 ppm (NIOSH, 2024)[1]
First aid
- Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Caution: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary.[1]
- Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)[1]
- General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[10]
- General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[10]
Storage
- Cool. Fireproof. Separated from : See Chemical Dangers. Store in an area without drain or sewer access.[3]
- Fireproof. Cool. Ventilation along the floor. Separated from strong acids, oxidants, aluminium, copper, copper alloys, mercury, zinc and food and feedstuffs. Store only in original container. Well closed. Store in an area without drain or sewer access.[3]
- Keep container tightly closed in a dry and well-ventilated place. Contents under pressure. Storage class (TRGS 510): 2A: Gases[6]
- They are extremely flammable products that should be stored in a well-ventilated area and protected from fire risk. (methylamines)[6]
Incompatibilities
- Incompatible materials: Strong oxidizing agents.[6]
- Dimethylamine is a medium strong base. Reacts violently with strong oxidizers; with mercury causing fire and explosion hazard. Incompatible with acids, organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls, alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks aluminum, copper, lead, tin, zinc and alloys, some plastics, rubber and coatings.[6]
- Incompatible with acryaldehyde, fluorine, and maleic anhydride.[6]
- May react with acids, oxidizing materials, chlorine, hypochlorite, halogenated compounds, reactive organic compounds, some metals, and mercury and nitrosating compounds.[6]
Safety data sheets on the supplier’s page: ChemFish Tokyo Co., Ltd., MolCore, Sigma-Aldrich.
Always read the supplier’s safety data sheet before working with it.
Spectra
- NMRNMRShiftDB
- 1H NMRHuman Metabolome Database (HMDB) (Varian · 500 MHz · Water) · SpectraBase (Varian CFT-20)
- 13C NMRHuman Metabolome Database (HMDB) (Bruker · 125 MHz · Water) · Human Metabolome Database (HMDB) (400 MHz · H2O) · SpectraBase
- 15N NMRSpectraBase
- 1H-13C NMRHuman Metabolome Database (HMDB) (Bruker · 600 MHz · Water)
- GC-MSHuman Metabolome Database (HMDB) (EI-B · positive) · MassBank of North America (MoNA) (HITACHI M-80B · EI-B · positive) · MassBank of North America (MoNA) (HITACHI M-80B · EI-B · positive) · NIST Mass Spectrometry Data Center · NIST Mass Spectrometry Data Center · NIST Mass Spectrometry Data Center
- MS-MSHuman Metabolome Database (HMDB) (LC-ESI-QQ · positive) · Human Metabolome Database (HMDB) (LC-ESI-QQ · positive) · Human Metabolome Database (HMDB) (LC-ESI-QQ · positive) · Human Metabolome Database (HMDB) (LC-ESI-QQ · positive) · Human Metabolome Database (HMDB) (LC-ESI-QQ · positive) · Human Metabolome Database (HMDB) (EI-B (HITACHI M-80B) · Positive)
- LC-MSMassBank Europe (API3000, Applied Biosystems · LC-ESI-QQ · POSITIVE) · MassBank Europe (API3000, Applied Biosystems · LC-ESI-QQ · POSITIVE) · MassBank Europe (API3000, Applied Biosystems · LC-ESI-QQ · POSITIVE) · MassBank Europe (API3000, Applied Biosystems · LC-ESI-QQ · POSITIVE) · MassBank Europe (API3000, Applied Biosystems · LC-ESI-QQ · POSITIVE) · MassBank of North America (MoNA) (API3000, Applied Biosystems · LC-ESI-QQ · positive)
- Other MSHazardous Substances Data Bank (HSDB) · MassBank Europe (HITACHI M-80B · EI-B · POSITIVE)
- UVHazardous Substances Data Bank (HSDB)
- IRHazardous Substances Data Bank (HSDB)
- FTIRSpectraBase (Film from the melt on KBr)
- ATR-IRSpectraBase
- Vapor Phase IRSpectraBase (Vapor Phase)
- RamanSpectraBase
Experimental spectra held by these sources; each link opens the source's own record.
Literature
Reading PubChem, OpenAlex and GSRS…
Bioactivity
Reading ChEMBL…
References
- [1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
- [2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
- [3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [4]Occupational Safety and Health Administration (OSHA) · Public domain (US DOL) · via PubChem · retrieved 2026-10-14
- [5]The National Institute for Occupational Safety and Health (NIOSH) · Public domain (US CDC) · via PubChem · retrieved 2026-10-14
- [6]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
- [7]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
- [8]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [9]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
- [10]Emergency Response Guidebook (ERG) · Public domain (US DOT) · via PubChem · retrieved 2026-10-14
- [11]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
- [12]Human Metabolome Database (HMDB) · Linked only · via PubChem · retrieved 2026-10-14
- [13]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
- [14]MassBank of North America (MoNA) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [15]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
- [16]MassBank Europe · Linked only · via PubChem · retrieved 2026-10-14
- ·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
- ·Literature on PubChem
Data last updated 2026-10-14.
