Library

Triethylamine

Athanor · official

C6H15N · 101.19 g/mol

IUPAC name: N,N-diethylethanamine

Also called NEt3, TEA, Et3N

Open in Athanor
The structure of Triethylamine
Drawn from its SMILES with RDKit330
FlammableCorrosiveAcute toxicityDangerHighly Flammable liquid and vapor · Toxic if swallowed · Toxic in contact with skin · Causes severe skin burns and eye damage · Causes serious eye damage · Toxic if inhaled

Names and identifiers

IUPAC name
N,N-diethylethanamine
Synonyms
NEt3, TEA, Et3N
+ 36 more

N,N-Diethylethanamine, (Diethylamino)ethane, Ethanamine, N,N-diethyl-, Triaethylamin, Trietilamina, DTXSID3024366, VOU728O6AY, TEN [Base], DTXCID204366, FEMA NO. 4246, CHEBI:35026, TEN (Base), RefChem:899489, 204-469-4, triethyl amine, Triethylamin, N,N,N-Triethylamine, Diethylaminoethane, MFCD00009051, trietylamine, tri-ethyl amine, (C2H5)3N, N,N-diethyl-ethanamine, ethane, diethylamino-, SCHEMBL30, Triethylamine, >=99.5%, Triaethylamin [German], Trietilamina [Italian], triethyl-amine, CCRIS 4881, HSDB 896, EINECS 204-469-4, UN1296, UNII-VOU728O6AY, triehtylamine, triehylamine

Molecular formula
C6H15N
Empirical formula
C6H15N
Molecular weight
101.19 g/mol
Exact mass
101.12045
CAS number
121-44-8
PubChem CID
8471
Canonical SMILES
CCN(CC)CC
Isomeric SMILES
CCN(CC)CC
InChI
InChI=1S/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H3
InChIKey
ZMANZCXQSJIPKH-UHFFFAOYSA-N
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Physical properties

TemperaturePressureDensity
Appearance
Colorless liquid[6]
6 values

From Hazardous Substances Data Bank (HSDB), the most authoritative source here.

ValueAs writtenSource
–Triethylamine appears as a clear colorless liquid with a strong ammonia to fish-like odor. Flash point 20 °F. Vapors irritate the eyes and mucous membranes. Less dense (6.1 lb / gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen when burned.[1] CAMEO Chemicals
–Liquid; CBI[2] EPA Chemical Data Reporting (CDR)
–COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–Colorless liquid with a strong, ammonia-like odor.[4] Occupational Safety and Health Administration (OSHA)
–Colorless liquid with a strong, ammonia-like odor.[5] The National Institute for Occupational Safety and Health (NIOSH)
–shownColorless liquid[6] Hazardous Substances Data Bank (HSDB)cites Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley's Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 1370
Odor
Fishy[6]
2 values

From Hazardous Substances Data Bank (HSDB), the most authoritative source here.

ValueAs writtenSource
–Strong, ammoniacal ordor[6] Hazardous Substances Data Bank (HSDB)cites Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley's Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 1370
–shownFishy[6] Hazardous Substances Data Bank (HSDB)cites U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
Melting point
-114.8 °C[7]
5 values

5 of 5 sources agree on it (most common value).

ValueAs writtenSource
−114.7 °C-174.5 °F (NTP, 1992)[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−115 °C-115 °C[3] ILO-WHO International Chemical Safety Cards (ICSCs)
−115 °C-175 °F[4] Occupational Safety and Health Administration (OSHA)
−114.8 °Cshown-114.8 °C[7] PAC Chemical Database, U.S. Department of Energy
−115 °C-175 °F[5] The National Institute for Occupational Safety and Health (NIOSH)
Boiling point
89.3 °C (192.7 °F) at 760 mmHg (NTP, 1992)[1]
5 values

5 of 5 sources agree on it (most common value).

ValueAs writtenSource
89.3 °Cshown192.7 °F at 760 mmHg (NTP, 1992)[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
89 °C89 °C[3] ILO-WHO International Chemical Safety Cards (ICSCs)
89 °C193 °F[4] Occupational Safety and Health Administration (OSHA)
89.5 °C89.5 °C @760 [mm Hg][7] PAC Chemical Database, U.S. Department of Energy
89 °C193 °F[5] The National Institute for Occupational Safety and Health (NIOSH)
Density
0.7255 @25 °C[7]
5 values

4 of 5 sources agree on it (most common value).

ValueAs writtenSource
–0.729 at 68 °F (USCG, 1999) - Less dense than water[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
–Relative density (water = 1): 0.7[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–0.73[4] Occupational Safety and Health Administration (OSHA)
–shown0.7255 @25 °C[7] PAC Chemical Database, U.S. Department of Energy
–0.73[5] The National Institute for Occupational Safety and Health (NIOSH)

5 more values were reported but failed the checks (unreadable or out of range), so they are not shown.

Solubility in water
Solubility in water, g/100ml at 20 °C: 17 (good)[3]
6 values

From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.

ValueAs writtenSource
–Soluble (NTP, 1992)[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–In water, 6.86X10+4 mg/L at 25 °C[6] Hazardous Substances Data Bank (HSDB)cites Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 334
–Soluble in fixed oils, mineral oil, oleic and stearic acids and in hot carnauba and paraffin waxes.[6] Hazardous Substances Data Bank (HSDB)cites Flick, E.W. (ed.). Industrial Solvents Handbook 4 th ed. Noyes Data Corporation., Park Ridge, NJ., 1991., p. 714
–For more Solubility (Complete) data for TRIETHYLAMINE (6 total), please visit the HSDB record page.[6] Hazardous Substances Data Bank (HSDB)
–shownSolubility in water, g/100ml at 20 °C: 17 (good)[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–2%[5] The National Institute for Occupational Safety and Health (NIOSH)
log P
1.45[3]
2 values

2 of 2 sources agree on it (most common value).

ValueAs writtenSource
–log Kow = 1.45[6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 25
–shown1.45[3] ILO-WHO International Chemical Safety Cards (ICSCs)
pKa
pKa = 10.78 at 25 °C[6]
2 values

Only one source reports it.

ValueAs writtenSource
–pKb = 3.25[6] Hazardous Substances Data Bank (HSDB)cites Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 1089
–shownpKa = 10.78 at 25 °C[6] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 638
Vapor pressure
57.07 mmHg at 25 °C[6]
2 values

Sources disagree; from Hazardous Substances Data Bank (HSDB), the most authoritative.

ValueAs writtenSource
57.07 mmHgshown57.07 mm Hg at 25 °C[6] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 638
54 mmHgVapor pressure, kPa at 20 °C: 7.2[3] ILO-WHO International Chemical Safety Cards (ICSCs)

3 more values were reported but failed the checks (unreadable or out of range), so they are not shown.

Flash point
-7 °C (20 °F, NTP 1992)[1]
6 values

3 of 5 sources agree on it (most common value).

ValueAs writtenSource
−7 °Cshown20 °F (NTP, 1992)[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−15 °C-15 °C (5 °F) - closed cup[6] Hazardous Substances Data Bank (HSDB)cites Sigma-Aldrich; Safety Data Sheet for Triethylamine. Product Number: T0886 Version 4.13 (Revision Date 05/24/2016). Available from, as of July 1, 2016: https://www.sigmaaldrich.com/safety-center.html
−9 °C16 °F (-7 °F) (open cup)[6] Hazardous Substances Data Bank (HSDB)cites National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14TH Edition, Quincy, MA 2010, p. 325-110
−17 °C-17 °C c.c.[3] ILO-WHO International Chemical Safety Cards (ICSCs)
−7 °C20 °F[4] Occupational Safety and Health Administration (OSHA)
−7 °C20 °F[5] The National Institute for Occupational Safety and Health (NIOSH)
Autoignition temperature
230 °C[3]
3 values

Sources disagree; from ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative.

ValueAs writtenSource
450 °C842 °F (USCG, 1999)[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
249 °C480 °F (249 °C)[6] Hazardous Substances Data Bank (HSDB)cites National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14TH Edition, Quincy, MA 2010, p. 325-110
230 °Cshown230 °C[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.

Calculated

Heavy atoms
7
Rings
0
Aromatic rings
0
Fraction sp³ carbons (Fsp3)
1
H-bond donors
0
H-bond acceptors
1
Rotatable bonds
3
TPSA (Ų)
3.2
Formal charge
0
XLogP3
1.4 PubChem
Complexity
25 PubChem
Stereocenters
None
Double-bond geometry
None specified
Point group
C1 of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

  • C71.22%
  • H14.94%
  • N13.84%

Isotope pattern

100%101.1207.0%102.124103.127

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P
1.35 Crippen (Wildman and Crippen 1999)
log S (water solubility)
-1.12 ESOL (Delaney 2004), log mol/L
Synthetic accessibility
1.9 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

  • Molecular weight ≤ 500: 101.19
  • log P ≤ 5 (Crippen): 1.35
  • H-bond donors ≤ 5: 0
  • H-bond acceptors ≤ 10: 1

Passes all four rules.

¹³C NMR shifts, predicted

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

Danger

Harmonized EU classification (CLP Annex VI). Source [8].

  • Flammable
  • Corrosive
  • Acute toxicity
330
NFPA 704[6]
  • H225Highly Flammable liquid and vapor
  • H301Toxic if swallowed
  • H311Toxic in contact with skin
  • H314Causes severe skin burns and eye damage
  • H318Causes serious eye damage
  • H331Toxic if inhaled

Precautionary statements: P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, P501

View all classifications (4)
  • [8] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH225, H301, H311, H314, H318, H331
  • [9] European Chemicals Agency (ECHA)This chemical does not meet GHS hazard criteria for < 0.1% (2 of 5716) of reports.
  • [9] European Chemicals Agency (ECHA) · 5,716 reports · DangerH302, H311, H312, H318, H331, H332, H335
  • [6] Hazardous Substances Data Bank (HSDB) · DangerH225, H302, H311, H314, H318, H331, H335, H401

Exposure limits

  • PEL-TWA (8-Hour Time Weighted Average): 25 ppm (100 mg/m³)[4]
  • PEL: TWA 25 ppm (100 mg/m3) See Appendix G[5]
  • REL: See Appendix D[5]
  • TLV: 0.5 ppm as TWA; 1 ppm as STEL; (skin); A4 (not classifiable as a human carcinogen).[3]
  • TLV-TWA (Time Weighted Average): 0.5 ppm [2014][4]
  • TLV-STEL (Short Term Exposure Limit): 1 ppm [2014][4]

First aid

  • Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]
  • General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[10]
  • (General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water.[5]
  • Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.[3]

Storage

  • Fireproof. Separated from incompatible materials and food and feedstuffs. See Chemical Dangers.[3]
  • Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids.[6]
  • Avoid oxidizing materials, acids, and sources of halogens. Store in cool, dry, well-ventilated location.[6]

Incompatibilities

  • Incompatible materials: Strong oxidizing agents.[6]
  • Toxic gases and vapors (such as oxides of nitrogen and carbon monoxide) may be released in fire involving triethylamine.[6]
  • Contact with strong acids may cause violent spattering.[6]
  • The complex, containing excess (dinitrogen tetraoxide) over ... (triethylamine), exploded at below 0 °C when free of solvent.[6]

Safety data sheets on the supplier’s page: Thermo Fisher Scientific, VladaChem, AA BLOCKS.

Always read the supplier’s safety data sheet before working with it.

Spectra

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

  1. [1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
  2. [2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
  3. [3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
  4. [4]Occupational Safety and Health Administration (OSHA) · Public domain (US DOL) · via PubChem · retrieved 2026-10-14
  5. [5]The National Institute for Occupational Safety and Health (NIOSH) · Public domain (US CDC) · via PubChem · retrieved 2026-10-14
  6. [6]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
  7. [7]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
  8. [8]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
  9. [9]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
  10. [10]Emergency Response Guidebook (ERG) · Public domain (US DOT) · via PubChem · retrieved 2026-10-14
  11. [11]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
  12. [12]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
  13. [13]Human Metabolome Database (HMDB) · Linked only · via PubChem · retrieved 2026-10-14
  14. [14]MassBank of North America (MoNA) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
  15. [15]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
  16. [16]MassBank Europe · Linked only · via PubChem · retrieved 2026-10-14
  17. ·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
  18. ·Literature on PubChem

Data last updated 2026-10-14.