Triethylamine
Athanor · official
C6H15N · 101.19 g/mol
IUPAC name: N,N-diethylethanamine
Also called NEt3, TEA, Et3N
Names and identifiers
- IUPAC name
- N,N-diethylethanamine
- Synonyms
- NEt3, TEA, Et3N
+ 36 more
N,N-Diethylethanamine, (Diethylamino)ethane, Ethanamine, N,N-diethyl-, Triaethylamin, Trietilamina, DTXSID3024366, VOU728O6AY, TEN [Base], DTXCID204366, FEMA NO. 4246, CHEBI:35026, TEN (Base), RefChem:899489, 204-469-4, triethyl amine, Triethylamin, N,N,N-Triethylamine, Diethylaminoethane, MFCD00009051, trietylamine, tri-ethyl amine, (C2H5)3N, N,N-diethyl-ethanamine, ethane, diethylamino-, SCHEMBL30, Triethylamine, >=99.5%, Triaethylamin [German], Trietilamina [Italian], triethyl-amine, CCRIS 4881, HSDB 896, EINECS 204-469-4, UN1296, UNII-VOU728O6AY, triehtylamine, triehylamine
- Molecular formula
- C6H15N
- Empirical formula
- C6H15N
- Molecular weight
- 101.19 g/mol
- Exact mass
- 101.12045
- CAS number
- 121-44-8
- PubChem CID
- 8471
- Canonical SMILES
- CCN(CC)CC
- Isomeric SMILES
- CCN(CC)CC
- InChI
- InChI=1S/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H3
- InChIKey
- ZMANZCXQSJIPKH-UHFFFAOYSA-N
- Molfile
Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.
Physical properties
- Appearance
- Colorless liquid[6]
6 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source – Triethylamine appears as a clear colorless liquid with a strong ammonia to fish-like odor. Flash point 20 °F. Vapors irritate the eyes and mucous membranes. Less dense (6.1 lb / gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen when burned. [1] CAMEO Chemicals – Liquid; CBI [2] EPA Chemical Data Reporting (CDR) – COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. [3] ILO-WHO International Chemical Safety Cards (ICSCs) – Colorless liquid with a strong, ammonia-like odor. [4] Occupational Safety and Health Administration (OSHA) – Colorless liquid with a strong, ammonia-like odor. [5] The National Institute for Occupational Safety and Health (NIOSH) –shown Colorless liquid [6] Hazardous Substances Data Bank (HSDB)cites Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley's Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 1370 - Odor
- Fishy[6]
2 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source – Strong, ammoniacal ordor [6] Hazardous Substances Data Bank (HSDB)cites Larranaga, M.D., Lewis, R.J. Sr., Lewis, R.A.; Hawley's Condensed Chemical Dictionary 16th Edition. John Wiley & Sons, Inc. Hoboken, NJ 2016., p. 1370 –shown Fishy [6] Hazardous Substances Data Bank (HSDB)cites U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5. - Melting point
- -114.8 °C[7]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source −114.7 °C -174.5 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. −115 °C -115 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) −115 °C -175 °F [4] Occupational Safety and Health Administration (OSHA) −114.8 °Cshown -114.8 °C [7] PAC Chemical Database, U.S. Department of Energy −115 °C -175 °F [5] The National Institute for Occupational Safety and Health (NIOSH) - Boiling point
- 89.3 °C (192.7 °F) at 760 mmHg (NTP, 1992)[1]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source 89.3 °Cshown 192.7 °F at 760 mmHg (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. 89 °C 89 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) 89 °C 193 °F [4] Occupational Safety and Health Administration (OSHA) 89.5 °C 89.5 °C @760 [mm Hg] [7] PAC Chemical Database, U.S. Department of Energy 89 °C 193 °F [5] The National Institute for Occupational Safety and Health (NIOSH) - Density
- 0.7255 @25 °C[7]
5 values
4 of 5 sources agree on it (most common value).
Value As written Source – 0.729 at 68 °F (USCG, 1999) - Less dense than water [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office. – Relative density (water = 1): 0.7 [3] ILO-WHO International Chemical Safety Cards (ICSCs) – 0.73 [4] Occupational Safety and Health Administration (OSHA) –shown 0.7255 @25 °C [7] PAC Chemical Database, U.S. Department of Energy – 0.73 [5] The National Institute for Occupational Safety and Health (NIOSH) 5 more values were reported but failed the checks (unreadable or out of range), so they are not shown.
- Solubility in water
- Solubility in water, g/100ml at 20 °C: 17 (good)[3]
6 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source – Soluble (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. – In water, 6.86X10+4 mg/L at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 334 – Soluble in fixed oils, mineral oil, oleic and stearic acids and in hot carnauba and paraffin waxes. [6] Hazardous Substances Data Bank (HSDB)cites Flick, E.W. (ed.). Industrial Solvents Handbook 4 th ed. Noyes Data Corporation., Park Ridge, NJ., 1991., p. 714 – For more Solubility (Complete) data for TRIETHYLAMINE (6 total), please visit the HSDB record page. [6] Hazardous Substances Data Bank (HSDB) –shown Solubility in water, g/100ml at 20 °C: 17 (good) [3] ILO-WHO International Chemical Safety Cards (ICSCs) – 2% [5] The National Institute for Occupational Safety and Health (NIOSH) - log P
- 1.45[3]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source – log Kow = 1.45 [6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 25 –shown 1.45 [3] ILO-WHO International Chemical Safety Cards (ICSCs) - pKa
- pKa = 10.78 at 25 °C[6]
2 values
Only one source reports it.
Value As written Source – pKb = 3.25 [6] Hazardous Substances Data Bank (HSDB)cites Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 1089 –shown pKa = 10.78 at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 638 - Vapor pressure
- 57.07 mmHg at 25 °C[6]
2 values
Sources disagree; from Hazardous Substances Data Bank (HSDB), the most authoritative.
Value As written Source 57.07 mmHgshown 57.07 mm Hg at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 638 54 mmHg Vapor pressure, kPa at 20 °C: 7.2 [3] ILO-WHO International Chemical Safety Cards (ICSCs) 3 more values were reported but failed the checks (unreadable or out of range), so they are not shown.
- Flash point
- -7 °C (20 °F, NTP 1992)[1]
6 values
3 of 5 sources agree on it (most common value).
Value As written Source −7 °Cshown 20 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. −15 °C -15 °C (5 °F) - closed cup [6] Hazardous Substances Data Bank (HSDB)cites Sigma-Aldrich; Safety Data Sheet for Triethylamine. Product Number: T0886 Version 4.13 (Revision Date 05/24/2016). Available from, as of July 1, 2016: https://www.sigmaaldrich.com/safety-center.html −9 °C 16 °F (-7 °F) (open cup) [6] Hazardous Substances Data Bank (HSDB)cites National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14TH Edition, Quincy, MA 2010, p. 325-110 −17 °C -17 °C c.c. [3] ILO-WHO International Chemical Safety Cards (ICSCs) −7 °C 20 °F [4] Occupational Safety and Health Administration (OSHA) −7 °C 20 °F [5] The National Institute for Occupational Safety and Health (NIOSH) - Autoignition temperature
- 230 °C[3]
3 values
Sources disagree; from ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative.
Value As written Source 450 °C 842 °F (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office. 249 °C 480 °F (249 °C) [6] Hazardous Substances Data Bank (HSDB)cites National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14TH Edition, Quincy, MA 2010, p. 325-110 230 °Cshown 230 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.
Calculated
- Heavy atoms
- 7
- Rings
- 0
- Aromatic rings
- 0
- Fraction sp³ carbons (Fsp3)
- 1
- H-bond donors
- 0
- H-bond acceptors
- 1
- Rotatable bonds
- 3
- TPSA (Ų)
- 3.2
- Formal charge
- 0
- XLogP3
- 1.4 PubChem
- Complexity
- 25 PubChem
- Stereocenters
- None
- Double-bond geometry
- None specified
- Point group
- C1 of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)
Elemental analysis
- C71.22%
- H14.94%
- N13.84%
Isotope pattern
Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.
Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.
Predicted
- log P
- 1.35 Crippen (Wildman and Crippen 1999)
- log S (water solubility)
- -1.12 ESOL (Delaney 2004), log mol/L
- Synthetic accessibility
- 1.9 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)
Drug-likeness: Lipinski’s rule of five
- Molecular weight ≤ 500: 101.19
- log P ≤ 5 (Crippen): 1.35
- H-bond donors ≤ 5: 0
- H-bond acceptors ≤ 10: 1
Passes all four rules.
¹³C NMR shifts, predicted
Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.
Safety
Danger
Harmonized EU classification (CLP Annex VI). Source [8].
Flammable
Corrosive
Acute toxicity
- H225Highly Flammable liquid and vapor
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
- H318Causes serious eye damage
- H331Toxic if inhaled
Precautionary statements: P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, P501
View all classifications (4)
- [8] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH225, H301, H311, H314, H318, H331
- [9] European Chemicals Agency (ECHA)This chemical does not meet GHS hazard criteria for < 0.1% (2 of 5716) of reports.
- [9] European Chemicals Agency (ECHA) · 5,716 reports · DangerH302, H311, H312, H318, H331, H332, H335
- [6] Hazardous Substances Data Bank (HSDB) · DangerH225, H302, H311, H314, H318, H331, H335, H401
Exposure limits
- PEL-TWA (8-Hour Time Weighted Average): 25 ppm (100 mg/m³)[4]
- PEL: TWA 25 ppm (100 mg/m3) See Appendix G[5]
- REL: See Appendix D[5]
- TLV: 0.5 ppm as TWA; 1 ppm as STEL; (skin); A4 (not classifiable as a human carcinogen).[3]
- TLV-TWA (Time Weighted Average): 0.5 ppm [2014][4]
- TLV-STEL (Short Term Exposure Limit): 1 ppm [2014][4]
First aid
- Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]
- General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[10]
- (General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water.[5]
- Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.[3]
Storage
- Fireproof. Separated from incompatible materials and food and feedstuffs. See Chemical Dangers.[3]
- Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids.[6]
- Avoid oxidizing materials, acids, and sources of halogens. Store in cool, dry, well-ventilated location.[6]
Incompatibilities
- Incompatible materials: Strong oxidizing agents.[6]
- Toxic gases and vapors (such as oxides of nitrogen and carbon monoxide) may be released in fire involving triethylamine.[6]
- Contact with strong acids may cause violent spattering.[6]
- The complex, containing excess (dinitrogen tetraoxide) over ... (triethylamine), exploded at below 0 °C when free of solvent.[6]
Safety data sheets on the supplier’s page: Thermo Fisher Scientific, VladaChem, AA BLOCKS.
Always read the supplier’s safety data sheet before working with it.
Spectra
- NMRHazardous Substances Data Bank (HSDB) · NMRShiftDB
- 1H NMRSpectraBase (BRUKER AC-300)
- 13C NMRHazardous Substances Data Bank (HSDB) · SpectraBase
- 15N NMRSpectraBase (Bruker WH-180)
- GC-MSHuman Metabolome Database (HMDB) (EI-B · positive) · MassBank of North America (MoNA) (HITACHI M-80A · EI-B · positive) · MassBank of North America (MoNA) (HITACHI M-80A · EI-B · positive) · NIST Mass Spectrometry Data Center · NIST Mass Spectrometry Data Center · NIST Mass Spectrometry Data Center
- LC-MSMassBank Europe (Vanquish UPHPLC - Q Exactive HF-X Orbitra, Thermo Scientific · LC-ESI-QFT · POSITIVE) · MassBank Europe (Vanquish UPHPLC - Q Exactive HF-X Orbitra, Thermo Scientific · LC-ESI-QFT · POSITIVE) · MassBank Europe (Vanquish UPHPLC - Q Exactive HF-X Orbitra, Thermo Scientific · LC-ESI-QFT · POSITIVE) · MassBank Europe (Orbitrap Q-Exactive HF-X, Thermo Scientific · LC-ESI-QFT · POSITIVE) · MassBank Europe (Orbitrap Q-Exactive HF-X, Thermo Scientific · LC-ESI-QFT · POSITIVE) · MassBank Europe (Vanquish Flex UHPLC system, Thermo Fisher Scientific - Orbitrap Q Exactive Plus mass spectrometer, Thermo Fisher Scientific · LC-ESI-QFT · POSITIVE)
- Other MSHazardous Substances Data Bank (HSDB) · MassBank Europe (HITACHI M-80A · EI-B · POSITIVE)
- UVHazardous Substances Data Bank (HSDB)
- IRHazardous Substances Data Bank (HSDB)
- FTIRSpectraBase (CELL: 0.015 mm)
- ATR-IRSpectraBase (Bruker Tensor 27 FT-IR · ATR-Neat (DuraSamplIR II))
- Near IRSpectraBase (BRUKER IFS 88 · NIR Spectrometer= INSTRUMENT PARAMETERS=INST=BRUKER,RSN=10262,REO=2,CNM=HEI,ZFF=2)
- Vapor Phase IRSpectraBase (Bruker IFS 85 · Gas-GC)
- RamanHazardous Substances Data Bank (HSDB) · SpectraBase (Bruker MultiRAM Stand Alone FT-Raman Spectrometer · FT-Raman)
Experimental spectra held by these sources; each link opens the source's own record.
Literature
Reading PubChem, OpenAlex and GSRS…
Bioactivity
Reading ChEMBL…
References
- [1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
- [2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
- [3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [4]Occupational Safety and Health Administration (OSHA) · Public domain (US DOL) · via PubChem · retrieved 2026-10-14
- [5]The National Institute for Occupational Safety and Health (NIOSH) · Public domain (US CDC) · via PubChem · retrieved 2026-10-14
- [6]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
- [7]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
- [8]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [9]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
- [10]Emergency Response Guidebook (ERG) · Public domain (US DOT) · via PubChem · retrieved 2026-10-14
- [11]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
- [12]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
- [13]Human Metabolome Database (HMDB) · Linked only · via PubChem · retrieved 2026-10-14
- [14]MassBank of North America (MoNA) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [15]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
- [16]MassBank Europe · Linked only · via PubChem · retrieved 2026-10-14
- ·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
- ·Literature on PubChem
Data last updated 2026-10-14.
