TEMED

Athanor · official

C₆H₁₆N₂ · 116.2 g/mol

IUPAC name: N,N,N',N'-tetramethylethane-1,2-diamine

Also called tetramethylethylenediamine, TMEDA, gel catalyst

Reagents

Open in Athanor

Drawn from its SMILES with RDKit

DangerHighly Flammable liquid and vapor · Harmful if swallowed · Causes severe skin burns and eye damage · Harmful if inhaled

Names and identifiers

IUPAC name: N,N,N',N'-tetramethylethane-1,2-diamine
Synonyms: tetramethylethylenediamine, TMEDA, gel catalyst
+ 37 more
N,N,N',N'-Tetramethylethylenediamine, Tetramethylethylenediamine, N,N,N',N'-tetramethylethane-1,2-diamine, 1,2-Bis(dimethylamino)ethane, Propamine D, Tetramethyldiaminoethane, Tetrameen, 1,2-Ethanediamine, N,N,N',N'-tetramethyl-, Tetramethyl ethylene diamine, N,N,N',N'-TETRAMETHYL-1,2-ETHANEDIAMINE, Ethylenediamine, N,N,N',N'-tetramethyl-, DTXSID5026122, N,N,N',N'-Tetramethyl-1,2-diaminoethane, Dimethyl(2-(dimethylamino)ethyl)amine, K90JUB7941, Dimethyl[2-(dimethylamino)ethyl]amine, DTXCID206122, CHEBI:32850, RefChem:926439, 203-744-6, N1,N1,N2,N2-Tetramethylethane-1,2-diamine, MFCD00008335, [2-(dimethylamino)ethyl]dimethylamine, tmen, 1,2-Bis-(dimethylamino)ethane, 1,2-Di-(dimethylamino)ethane, N,N,N',N'-tetramethyl-ethane-1,2-diamine, Potassium Clavulanate EP Impurity J, N,N,N',N'-TETRAMETHYL-ETHYLENEDIAMINE, 1,2-Ethanediamine, N1,N1,N2,N2-tetramethyl-, N~1~,N~1~,N~2~,N~2~-tetramethylethane-1,2-diamine, CCRIS 4870, HSDB 5396, N,N,N,N-Tetramethylethylenediamine, EINECS 203-744-6, UN2372, UNII-K90JUB7941
Molecular formula: C₆H₁₆N₂
Empirical formula: C₃H₈N
Molecular weight: 116.2 g/mol
Exact mass: 116.13135
CAS number: 110-18-9
PubChem CID: 8037
Canonical SMILES: CN(C)CCN(C)C
Isomeric SMILES: CN(C)CCN(C)C
InChI: InChI=1S/C6H16N2/c1-7(2)5-6-8(3)4/h5-6H2,1-4H3
InChIKey: KWYHDKDOAIKMQN-UHFFFAOYSA-N
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Physical properties

TemperaturePressureDensity

Appearance: Colorless liquid[3]
3 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
– 1,2-di-(dimethylamino)ethane appears as a water-white colored liquid with a fishlike odor. Flash point 68 °F. Less dense than water. Vapors heavier than air. Used to make other chemicals. [1] CAMEO Chemicals
– Liquid [2] EPA Chemical Data Reporting (CDR)
–shown Colorless liquid [3] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 1134
Odor: Slight ammoniacal odor[3]
Melting point: -55.1 °C (-67.2 °F, NTP 1992)[1]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source
−55.1 °Cshown -67.2 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−55 °C -55 °C [4] PAC Chemical Database, U.S. Department of Energy
Boiling point: 121 to 122 °C (250 to 252 °F) at 760 mmHg (NTP, 1992)[1]
Density: 0.7765 @ 20 °C/4 °C[3]
3 values
Only one source reports it.
Value As written Source
– 0.7765 at 68 °F (NTP, 1992) - Less dense than water [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
0.7765 g/mLshown 0.7765 @ 20 °C/4 °C [3] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 1134
– 0.77 @25 °C [4] PAC Chemical Database, U.S. Department of Energy
Solubility in water: Sol in water and most organic solvents[3]
2 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
– Soluble (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–shown Sol in water and most organic solvents [3] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 1134
log P: log Kow= 0.30[3]
Flash point: 10 °C (50 °F, NTP 1992)[1]

Value	As written	Source
–	1,2-di-(dimethylamino)ethane appears as a water-white colored liquid with a fishlike odor. Flash point 68 °F. Less dense than water. Vapors heavier than air. Used to make other chemicals.	[1] CAMEO Chemicals
–	Liquid	[2] EPA Chemical Data Reporting (CDR)
–shown	Colorless liquid	[3] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 1134

Value	As written	Source
−55.1 °Cshown	-67.2 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−55 °C	-55 °C	[4] PAC Chemical Database, U.S. Department of Energy

Value	As written	Source
–	0.7765 at 68 °F (NTP, 1992) - Less dense than water	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
0.7765 g/mLshown	0.7765 @ 20 °C/4 °C	[3] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 1134
–	0.77 @25 °C	[4] PAC Chemical Database, U.S. Department of Energy

Value	As written	Source
–	Soluble (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–shown	Sol in water and most organic solvents	[3] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 1134

Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.

Calculated

Heavy atoms: 8
Rings: 0
Aromatic rings: 0
Fraction sp³ carbons (Fsp3): 1
H-bond donors: 0
H-bond acceptors: 2
Rotatable bonds: 3
TPSA (Å²): 6.5
Formal charge: 0
XLogP3: 0.3 PubChem
Complexity: 42 PubChem
Stereocenters: None
Double-bond geometry: None specified
Point group: C1 of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

C62.01%
H13.88%
N24.11%

Isotope pattern

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P: 0.11 Crippen (Wildman and Crippen 1999)
log S (water solubility): -0.43 ESOL (Delaney 2004), log mol/L
Synthetic accessibility: 1.87 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

Molecular weight ≤ 500: 116.21
log P ≤ 5 (Crippen): 0.11
H-bond donors ≤ 5: 0
H-bond acceptors ≤ 10: 2

Passes all four rules.

¹³C NMR shifts, predicted

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

Danger

Harmonized EU classification (CLP Annex VI). Source [5].

Flammable
Corrosive
Harmful or irritant

H225Highly Flammable liquid and vapor
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H332Harmful if inhaled

Precautionary statements: P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, P501

View all classifications (2)

[5] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH225, H302, H314, H332
[6] European Chemicals Agency (ECHA) · 573 reports · DangerH225, H302+H332, H302, H314, H318, H331, H332, H411

First aid

Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]

Incompatibilities

... Can react with oxidizing materials.[3]

Safety data sheets on the supplier’s page: Thermo Fisher Scientific, Fluorochem, AA BLOCKS.

Always read the supplier’s safety data sheet before working with it.

Spectra

NMRHazardous Substances Data Bank (HSDB) · NMRShiftDB
1H NMRSpectraBase (Varian A-60)
13C NMRSpectraBase
15N NMRSpectraBase
GC-MSNIST Mass Spectrometry Data Center · NIST Mass Spectrometry Data Center · NIST Mass Spectrometry Data Center · SpectraBase (CH5)
IRHazardous Substances Data Bank (HSDB)
FTIRSpectraBase (BETWEEN SALTS)
ATR-IRSpectraBase (PerkinElmer SpectrumTwo · ATR-IR)
Near IRSpectraBase (INSTRUMENT PARAMETERS=INST=BRUKER,RSN=9169,REO=2,CNM=HEI,ZFF=2 · NIR Spectrometer= BRUKER IFS 88)
Vapor Phase IRSpectraBase (DIGILAB FTS-14 · Vapor Phase)
RamanSpectraBase

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

[1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
[2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
[3]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
[4]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
[5]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
[6]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
[7]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
[8]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
[9]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
·Literature on PubChem

Data last updated 2026-10-14.