SDS

Athanor · official

C₁₂H₂₅NaO₄S · 288.38 g/mol

IUPAC name: sodium dodecyl sulfate

Also called sodium dodecyl sulfate, sodium lauryl sulfate, SLS, SDS-PAGE

Reagents

Open in Athanor

Drawn from its SMILES with RDKit

DangerFlammable solid · Harmful if swallowed · Causes skin irritation · Causes serious eye damage · Causes serious eye irritation · Harmful if inhaled · May cause respiratory irritation · Harmful to aquatic life with long lasting effects

Names and identifiers

IUPAC name: sodium dodecyl sulfate
Synonyms: sodium dodecyl sulfate, sodium lauryl sulfate, SLS
+ 40 more
SDS-PAGE, Sodium dodecyl sulfate, SODIUM LAURYL SULFATE, Sodium dodecylsulfate, Sodium lauryl sulphate, Sodium dodecyl sulphate, Neutrazyme, Sodium n-dodecyl sulfate, Duponol C, Dodecyl sodium sulfate, Anticerumen, Duponal, Gardinol, Stepanol methyl, Stepanol wac, Stepanol waq, Perlandrol L, Perlankrol L, Stepanol me dry, Sintapon L, Finasol osr2, Standapol WAQ, Stepanol WA, Duponol QC, Incronol SLS, Maprobix NEU, Melanol CL, Dupanol WAQ, Duponol WA dry, Hexamol SLS, Duponol WAQE, Natriumlaurylsulfat, Sipex SP, Sipex UB, Sterling WAQ-CH, Stepanol WA Paste, Dodecyl sulfate, sodium salt, Avirol 118 conc, Duponol, Dreft
Molecular formula: C₁₂H₂₅NaO₄S
Empirical formula: C₁₂H₂₅NaO₄S
Molecular weight: 288.38 g/mol
Exact mass: 288.13712
CAS number: 151-21-3
PubChem CID: 3423265
Canonical SMILES: CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+]
Isomeric SMILES: CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+]
InChI: InChI=1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1
InChIKey: DBMJMQXJHONAFJ-UHFFFAOYSA-M
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Physical properties

TemperaturePressureDensity

Appearance: Small, white or light-yellow crystals[4]
5 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
– Dodecyl sulfate, [sodium salt] appears as white to pale yellow paste or liquid with a mild odor. Sinks and mixes with water. (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
– Liquid; Dry Powder; Liquid; Liquid; Other Solid; Large Crystals; CBI; Dry Powder; Other Solid [2] EPA Chemical Data Reporting (CDR)
– WHITE SOLID IN VARIOUS FORMS WITH CHARACTERISTIC ODOUR. [3] ILO-WHO International Chemical Safety Cards (ICSCs)
–shown Small, white or light-yellow crystals [4] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 1148
– White to cream-colored crystals, flakes or powder [4] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. V3: 3258
Odor: Slight, characteristic odor[4]
Melting point: 204 °C[3]
3 values
3 of 3 sources agree on it (most common value).
Value As written Source
204 to 207 °C 399 to 405 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
204 °Cshown 204 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
205 °C 205 °C [5] PAC Chemical Database, U.S. Department of Energy
Density: greater than 1.1 at 20 °C (68 °F, USCG 1999)[1]
Solubility in water: Solubility in water, g/100ml at 20 °C: 15 (moderate)[3]
3 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source
– less than 1 mg/mL at 66 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
– In water, 1.00X10+5 mg/L (temp not specified) [4] Hazardous Substances Data Bank (HSDB)cites PMID:8234943 Singer MM, Tjeerdema RS; Rev Environ Contam Toxicol 133: 95-149 (1993)
–shown Solubility in water, g/100ml at 20 °C: 15 (moderate) [3] ILO-WHO International Chemical Safety Cards (ICSCs)
log P: log Kow = 1.60[4]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source
–shown log Kow = 1.60 [4] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 107
– 1.6 [3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
–	Dodecyl sulfate, [sodium salt] appears as white to pale yellow paste or liquid with a mild odor. Sinks and mixes with water. (USCG, 1999)	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
–	Liquid; Dry Powder; Liquid; Liquid; Other Solid; Large Crystals; CBI; Dry Powder; Other Solid	[2] EPA Chemical Data Reporting (CDR)
–	WHITE SOLID IN VARIOUS FORMS WITH CHARACTERISTIC ODOUR.	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–shown	Small, white or light-yellow crystals	[4] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 1148
–	White to cream-colored crystals, flakes or powder	[4] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. V3: 3258

Value	As written	Source
204 to 207 °C	399 to 405 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
204 °Cshown	204 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
205 °C	205 °C	[5] PAC Chemical Database, U.S. Department of Energy

Value	As written	Source
–	less than 1 mg/mL at 66 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–	In water, 1.00X10+5 mg/L (temp not specified)	[4] Hazardous Substances Data Bank (HSDB)cites PMID:8234943 Singer MM, Tjeerdema RS; Rev Environ Contam Toxicol 133: 95-149 (1993)
–shown	Solubility in water, g/100ml at 20 °C: 15 (moderate)	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
–shown	log Kow = 1.60	[4] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 107
–	1.6	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.

Calculated

Heavy atoms: 18
Rings: 0
Aromatic rings: 0
Fraction sp³ carbons (Fsp3): 1
H-bond donors: 0
H-bond acceptors: 4
Rotatable bonds: 12
TPSA (Å²): 66.4 computed here · PubChem 74.8
Formal charge: 0
Complexity: 249 PubChem
Stereocenters: None
Double-bond geometry: None specified
Point group: C1 of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

C49.98%
H8.74%
Na7.97%
O22.19%
S11.12%

Isotope pattern

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P: 0.39 Crippen (Wildman and Crippen 1999)
log S (water solubility): -1.08 ESOL (Delaney 2004), log mol/L
Synthetic accessibility: 2.63 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

Molecular weight ≤ 500: 288.38
log P ≤ 5 (Crippen): 0.39
H-bond donors ≤ 5: 0
H-bond acceptors ≤ 10: 4

Passes all four rules.

¹³C NMR shifts, predicted

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

Danger

Most widely reported: 2,658 company reports to ECHA. Source [6].

Flammable
Corrosive
Harmful or irritant

H228Flammable solid (38.9% of reports)
H302Harmful if swallowed (93.7% of reports)
H315Causes skin irritation (98.2% of reports)
H318Causes serious eye damage (52.3% of reports)
H319Causes serious eye irritation (39.8% of reports)
H332Harmful if inhaled (14.8% of reports)
H335May cause respiratory irritation (38.7% of reports)
H412Harmful to aquatic life with long lasting effects (40.2% of reports)

Precautionary statements: P210, P240, P241, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, P501

View all classifications (4)

[6] European Chemicals Agency (ECHA)This chemical does not meet GHS hazard criteria for 0.9% (24 of 2658) of reports.
[6] European Chemicals Agency (ECHA) · 2,658 reports · DangerH228, H302, H315, H318, H319, H332, H335, H412
[6] European Chemicals Agency (ECHA) · 6 reports · WarningH302
[4] Hazardous Substances Data Bank (HSDB) · DangerH228, H302, H311, H315, H318, H335, H401

First aid

Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]
Fresh air, rest.[3]
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .[3]
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.[3]

Storage

Separated from strong oxidants and strong acids. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.[3]
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic[4]

Incompatibilities

Conditions to avoid: Heat, flames and sparks. Extremes of temperature and direct sunlight. Incompatible materials: Oxidizing agents[4]

Safety data sheets on the supplier’s page: Shenghe Chemical, MolCore, Alfa Chemistry.

Always read the supplier’s safety data sheet before working with it.

Spectra

1H NMRSpectraBase (Varian A-60D)
13C NMRSpectraBase
FTIRSpectraBase (FILM)
ATR-IRSpectraBase (PerkinElmer SpectrumTwo · ATR-IR)
RamanSpectraBase (Thermo Nicolet FT-Raman 960 · FT-Raman)

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

[1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
[2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
[3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[4]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
[5]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
[6]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
[7]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
·Literature on PubChem

Data last updated 2026-10-14.