4-Nitroaniline

Athanor · official

C₆H₆N₂O₂ · 138.12 g/mol

Also called p-nitroaniline, PNA, azo dye precursor

Reagents Rings

Open in Athanor

Drawn from its SMILES with RDKit

DangerToxic if swallowed · Toxic in contact with skin · Toxic if inhaled · Harmful to aquatic life with long lasting effects

Names and identifiers

IUPAC name: 4-nitroaniline
Synonyms: p-nitroaniline, PNA, azo dye precursor
+ 38 more
p-Nitroaniline, 4-Nitrobenzenamine, p-Nitraniline, p-Aminonitrobenzene, p-Nitrophenylamine, 1-Amino-4-nitrobenzene, 4-Nitraniline, Benzenamine, 4-nitro-, Developer P, Aniline, 4-nitro-, Fast Red P Base, Aniline, p-nitro-, Fast Red Base GG, Fast Red 2G Base, Fast Red Base 2J, para-Nitroaniline, Azoamine Red ZH, Nitrazol CF extra, Devol Red GG, Fast Red P Salt, Fast Red GG Base, Fast Red GG Salt, Fast Red MP Base, Fast Red Salt GG, Diazo Fast Red GG, Red 2G Base, Fast Red 2G Salt, Fast Red Salt 2J, Azofix Red GG Salt, C.I. Developer 17, Naphtoelan Red GG Base, p-Nitroanilina, Azoic Diazo Component 37, Shinnippon Fast Red GG Base, CI Developer 17, Rcra waste number P077, DTXSID8020961, para-Aminonitrobenzene
Molecular formula: C₆H₆N₂O₂
Empirical formula: C₃H₃NO
Molecular weight: 138.12 g/mol
Exact mass: 138.04293
CAS number: 100-01-6
PubChem CID: 7475
Canonical SMILES: C1=CC(=CC=C1N)[N+](=O)[O-]
Isomeric SMILES: C1=CC(=CC=C1N)[N+](=O)[O-]
InChI: InChI=1S/C6H6N2O2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H,7H2
InChIKey: TYMLOMAKGOJONV-UHFFFAOYSA-N
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Physical properties

TemperaturePressureDensity

Appearance: Bright yellow, crystalline powder.[6]
6 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
– P-nitroaniline, [solid] is a yellow solid with a mild odor. Sinks in water. (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
– Dry Powder [2] EPA Chemical Data Reporting (CDR)
– YELLOW CRYSTALS OR POWDER. [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– Bright yellow, crystalline powder with a slight ammonia-like odor. [4] Occupational Safety and Health Administration (OSHA)
– Bright yellow, crystalline powder with a slight ammonia-like odor. [5] The National Institute for Occupational Safety and Health (NIOSH)
–shown Bright yellow, crystalline powder. [6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)
Odor: Odorless[6]
3 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
– Faint ammonia; slightly pungent [6] Hazardous Substances Data Bank (HSDB)cites U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
–shown Odorless [6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2
– Slight ammonia-like odor. [6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)
Melting point: 147.5 °C[7]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source
148 °C 298 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
148 °C 148 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
146 °C 295 °F [4] Occupational Safety and Health Administration (OSHA)
147.5 °Cshown 147.5 °C [7] PAC Chemical Database, U.S. Department of Energy
146 °C 295 °F [5] The National Institute for Occupational Safety and Health (NIOSH)
Boiling point: 332 °C[3]
5 values
4 of 5 sources agree on it (most common value).
Value As written Source
336 °C 637 °F at 760 mmHg (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
332 °Cshown 332 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
332 °C 630 °F [4] Occupational Safety and Health Administration (OSHA)
332 °C 332 °C @760 [mm Hg] [7] PAC Chemical Database, U.S. Department of Energy
332 °C 630 °F [5] The National Institute for Occupational Safety and Health (NIOSH)
Density: 1.424 @ 20°C[7]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source
– 1.44 at 68 °F (USCG, 1999) - Denser than water [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
– 1.4 g/cm³ [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– 1.42 [4] Occupational Safety and Health Administration (OSHA)
–shown 1.424 @ 20°C [7] PAC Chemical Database, U.S. Department of Energy
– 1.42 [5] The National Institute for Occupational Safety and Health (NIOSH)
Solubility in water: Solubility in water, g/100ml at 18.5 °C: 0.08[3]
7 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source
– less than 0.1 mg/mL at 70 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
– Very soluble in methanol; soluble in ethanol, ether, acetone, chloroform, toluene; slightly soluble in benzene, deuterated DMSO [6] Hazardous Substances Data Bank (HSDB)cites Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V1: 551
– 0.08 g/100 g water at 18.5 °C. [6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2
– In water, 390 ppm at 20 °C [6] Hazardous Substances Data Bank (HSDB)cites Hashimoto Y et al; Chemosphere 11: 991-1003 (1982)
– For more Solubility (Complete) data for 4-NITROANILINE (7 total), please visit the HSDB record page. [6] Hazardous Substances Data Bank (HSDB)
–shown Solubility in water, g/100ml at 18.5 °C: 0.08 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– 0.08% [5] The National Institute for Occupational Safety and Health (NIOSH)
log P: 2.66[3]
2 values
Sources disagree; from ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative.
Value As written Source
– log Kow = 1.39 [6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 19
–shown 2.66 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
pKa: pKa = 1.01[6]
Vapor pressure: Vapor pressure, Pa at 20 °C: 0.2[3]
4 values
2 of 3 sources agree on it (most common value).
Value As written Source
0.0015 mmHg 0.0015 mmHg at 68 °F [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
0.007 mmHg 0.007 mmHg at 86 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
0.0000032 mmHg 3.2X10-6 mm Hg at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Ferro D, Piacente V; Thermochim Acta 90: 387-9 (1985)
0.0015 mmHgshown Vapor pressure, Pa at 20 °C: 0.2 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
2 more values were reported but failed the checks (unreadable or out of range), so they are not shown.
Flash point: 199 °C[3]
6 values
5 of 5 sources agree on it (most common value).
Value As written Source
199 °C 390 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
165 °C 329 °F (OPEN CUP) (MOLTEN SOLID) [6] Hazardous Substances Data Bank (HSDB)cites U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
199 °C 199 °C (closed cup) [6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2
199 °Cshown 199 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
199 °C 390 °F [4] Occupational Safety and Health Administration (OSHA)
199 °C 390 °F [5] The National Institute for Occupational Safety and Health (NIOSH)
Autoignition temperature: 180 °C (356 °F)[6]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source
180 °C 356 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
180 °Cshown 180 °C (356 °F) [6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2

Value	As written	Source
–	P-nitroaniline, [solid] is a yellow solid with a mild odor. Sinks in water. (USCG, 1999)	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
–	Dry Powder	[2] EPA Chemical Data Reporting (CDR)
–	YELLOW CRYSTALS OR POWDER.	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	Bright yellow, crystalline powder with a slight ammonia-like odor.	[4] Occupational Safety and Health Administration (OSHA)
–	Bright yellow, crystalline powder with a slight ammonia-like odor.	[5] The National Institute for Occupational Safety and Health (NIOSH)
–shown	Bright yellow, crystalline powder.	[6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)

Value	As written	Source
–	Faint ammonia; slightly pungent	[6] Hazardous Substances Data Bank (HSDB)cites U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
–shown	Odorless	[6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2
–	Slight ammonia-like odor.	[6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)

Value	As written	Source
148 °C	298 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
148 °C	148 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
146 °C	295 °F	[4] Occupational Safety and Health Administration (OSHA)
147.5 °Cshown	147.5 °C	[7] PAC Chemical Database, U.S. Department of Energy
146 °C	295 °F	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
336 °C	637 °F at 760 mmHg (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
332 °Cshown	332 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
332 °C	630 °F	[4] Occupational Safety and Health Administration (OSHA)
332 °C	332 °C @760 [mm Hg]	[7] PAC Chemical Database, U.S. Department of Energy
332 °C	630 °F	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	1.44 at 68 °F (USCG, 1999) - Denser than water	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
–	1.4 g/cm³	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	1.42	[4] Occupational Safety and Health Administration (OSHA)
–shown	1.424 @ 20°C	[7] PAC Chemical Database, U.S. Department of Energy
–	1.42	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	less than 0.1 mg/mL at 70 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–	Very soluble in methanol; soluble in ethanol, ether, acetone, chloroform, toluene; slightly soluble in benzene, deuterated DMSO	[6] Hazardous Substances Data Bank (HSDB)cites Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V1: 551
–	0.08 g/100 g water at 18.5 °C.	[6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2
–	In water, 390 ppm at 20 °C	[6] Hazardous Substances Data Bank (HSDB)cites Hashimoto Y et al; Chemosphere 11: 991-1003 (1982)
–	For more Solubility (Complete) data for 4-NITROANILINE (7 total), please visit the HSDB record page.	[6] Hazardous Substances Data Bank (HSDB)
–shown	Solubility in water, g/100ml at 18.5 °C: 0.08	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	0.08%	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	log Kow = 1.39	[6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 19
–shown	2.66	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
0.0015 mmHg	0.0015 mmHg at 68 °F	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
0.007 mmHg	0.007 mmHg at 86 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
0.0000032 mmHg	3.2X10-6 mm Hg at 25 °C	[6] Hazardous Substances Data Bank (HSDB)cites Ferro D, Piacente V; Thermochim Acta 90: 387-9 (1985)
0.0015 mmHgshown	Vapor pressure, Pa at 20 °C: 0.2	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
199 °C	390 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
165 °C	329 °F (OPEN CUP) (MOLTEN SOLID)	[6] Hazardous Substances Data Bank (HSDB)cites U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
199 °C	199 °C (closed cup)	[6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2
199 °Cshown	199 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
199 °C	390 °F	[4] Occupational Safety and Health Administration (OSHA)
199 °C	390 °F	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
180 °C	356 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
180 °Cshown	180 °C (356 °F)	[6] Hazardous Substances Data Bank (HSDB)cites Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2

Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.

Calculated

Heavy atoms: 10
Rings: 1
Aromatic rings: 1
Fraction sp³ carbons (Fsp3): 0
H-bond donors: 1
H-bond acceptors: 3
Rotatable bonds: 1 computed here · PubChem 0
TPSA (Å²): 69.2 computed here · PubChem 71.8
Formal charge: 0
XLogP3: 1.4 PubChem
Complexity: 124 PubChem
Stereocenters: None
Double-bond geometry: None specified
Point group: Cs of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

C52.17%
H4.38%
N20.28%
O23.17%

Isotope pattern

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P: 1.18 Crippen (Wildman and Crippen 1999)
log S (water solubility): -1.82 ESOL (Delaney 2004), log mol/L
Synthetic accessibility: 1.67 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

Molecular weight ≤ 500: 138.13
log P ≤ 5 (Crippen): 1.18
H-bond donors ≤ 5: 1
H-bond acceptors ≤ 10: 3

Passes all four rules.

¹³C NMR shifts, predicted

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

Danger

Harmonized EU classification (CLP Annex VI). Source [8].

Acute toxicity
Health hazard

NFPA 704[6]

H301Toxic if swallowed
H311Toxic in contact with skin
H331Toxic if inhaled
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P319, P321, P330, P361+P364, P403+P233, P405, P501

View all classifications (2)

[8] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH301, H311, H331, H412
[9] European Chemicals Agency (ECHA) · 108 reports · DangerH301+H311+H331, H301, H311, H331, H373, H412

Exposure limits

PEL-TWA (8-Hour Time Weighted Average): 1 ppm (6 mg/m³)[4]
PEL: TWA 6 mg/m3 (1 ppm) [skin] See Appendix G[5]
REL-TWA (Time Weighted Average): 3 mg/m³[4]
REL: TWA 3 mg/m3 [skin][5]
TLV: 3 mg/m[3]
TLV-TWA (Time Weighted Average): 3 mg/m³ [1992][4]

First aid

Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]
(General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water.[5]
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.[3]
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .[3]

Storage

Separated from strong acids, strong oxidants, combustible substances, reducing agents and food and feedstuffs. Dry.[3]
Store in a cool, dry, well-ventilated location. Separate from acids, oxidizing materials, & reducing agents.[6]

Incompatibilities

An ammonical soln of 4-nitroaniline containing ammonium chloride was being treated with 50% sodium hydroxide soln to displace ammonia. In error, double the amt required to give usual 10% of free alkali was added, & during subsequent degassing operation (heating to 130 °C under pressure, followed by depressuring to vent ammonia), complete conversion to sodium 4-nitrophenoxide occurred. ... (when) separated by centrifuging, it was then heated to dry ... When it decomposed violently & was ejected through the vessel opening. ...[6]
Incompatible with reducers.[6]
Incompatabilities: Strong oxidizers and moisture may result in spontaneous heating.[6]
For more Hazardous Reactivities and Incompatibilities (Complete) data for 4-nitroaniline (6 total), please visit the HSDB record page.[6]

Safety data sheets on the supplier’s page: RR Scientific, MolCore, TimTec.

Always read the supplier’s safety data sheet before working with it.

Spectra

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

[1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
[2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
[3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[4]Occupational Safety and Health Administration (OSHA) · Public domain (US DOL) · via PubChem · retrieved 2026-10-14
[5]The National Institute for Occupational Safety and Health (NIOSH) · Public domain (US CDC) · via PubChem · retrieved 2026-10-14
[6]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
[7]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
[8]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
[9]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
[10]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
[11]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
[12]MassBank of North America (MoNA) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[13]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
[14]Human Metabolome Database (HMDB) · Linked only · via PubChem · retrieved 2026-10-14
[15]MassBank Europe · Linked only · via PubChem · retrieved 2026-10-14
·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
·Literature on PubChem

Data last updated 2026-10-14.