Acrylamide
Athanor · official
C3H5NO · 71.08 g/mol
IUPAC name: prop-2-enamide
Also called prop-2-enamide, SDS-PAGE monomer, acrylic amide
Names and identifiers
- IUPAC name
- prop-2-enamide
- Synonyms
- prop-2-enamide, SDS-PAGE monomer, acrylic amide
+ 37 more
2-Propenamide, Propenamide, Acrylic acid amide, Acrylic amide, Ethylenecarboxamide, Vinyl amide, Akrylamid, Acrylagel, Propeneamide, Optimum, Amresco Acryl-40, Propenoic acid amide, Ethylene Carboxamide, Amid kyseliny akrylove, RCRA waste number U007, Acrylamide Monomer, DTXSID5020027, 20R035KLCI, CHEBI:28619, AI3-04119, NSC-7785, DTXCID6027, RefChem:5514, Acrylic acid amide (50%), 201-173-7, 2-Propeneamide, Akrylamid [Czech], Amide propenoic acid, CASEIN PEPTONE, Amid kyseliny akrylove [Czech], acryl amide, Flokonit E, Acrylamide Monome, Stipix AD, NSC 7785, Superfloc 84, Sumitex A 1
- Molecular formula
- C3H5NO
- Empirical formula
- C3H5NO
- Molecular weight
- 71.08 g/mol
- Exact mass
- 71.03711
- CAS number
- 79-06-1
- PubChem CID
- 6579
- Canonical SMILES
- C=CC(=O)N
- Isomeric SMILES
- C=CC(=O)N
- InChI
- InChI=1S/C3H5NO/c1-2-3(4)5/h2H,1H2,(H2,4,5)
- InChIKey
- HRPVXLWXLXDGHG-UHFFFAOYSA-N
- Molfile
Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.
Physical properties
- Appearance
- White crystalline ... solid[6]
8 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source – Acrylamide appears as white crystalline solid shipped either as a solid or in solution. A confirmed carcinogen. Toxic by skin absorption. Less dense than water and soluble in water. May be toxic by ingestion. Used for sewage and waste treatment, to make dyes, adhesives. The solid is stable at room temperature, but upon melting may violently polymerize. Toxic, irritating to skin, eyes, etc. [1] CAMEO Chemicals – Acrylamide solution, [aqueous] appears as a colorless aqueous solution of a solid. Often at a concentration of 40% (w/v). Spills can easily penetrate the soil and contaminate groundwater and nearby streams. Used for sewage and waste treatment and to make dyes and adhesives. Toxic, irritating to skin, eyes, etc. Produce toxic oxides of nitrogen when burned. [1] CAMEO Chemicals – Acrylamide solution, [flammable liquid label] appears as a solution of a colorless crystalline solid. Flash point depends on the solvent but below 141 °F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used for sewage and waste treatment, to make dyes and adhesives. [1] CAMEO Chemicals – Liquid; Other Solid [2] EPA Chemical Data Reporting (CDR) – WHITE CRYSTALS. [3] ILO-WHO International Chemical Safety Cards (ICSCs) – White crystalline, odorless solid. [4] Occupational Safety and Health Administration (OSHA) – White crystalline, odorless solid. [5] The National Institute for Occupational Safety and Health (NIOSH) –shown White crystalline ... solid [6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg - Odor
- Odorless[6]
- Melting point
- 84.5 °C[3]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source 84 °C 184 °F (EPA, 1998) [1] CAMEO Chemicalscites U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office. 84.5 °Cshown 84.5 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) 84 °C 184 °F [4] Occupational Safety and Health Administration (OSHA) 84.5 °C 84.5 °C [7] PAC Chemical Database, U.S. Department of Energy 84 °C 184 °F [5] The National Institute for Occupational Safety and Health (NIOSH) - Boiling point
- 175-300 °C (347-572 °F, Decomposes)[5]
4 values
2 of 3 sources agree on it (most common value).
Value As written Source 87 °C 189 °F at 2 mmHg (EPA, 1998) [1] CAMEO Chemicalscites U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office. 175 to 300 °C 347-572 °F (decomposes) [4] Occupational Safety and Health Administration (OSHA) 125 °C 125 °C @760 [mm Hg] [7] PAC Chemical Database, U.S. Department of Energy 175 to 300 °Cshown 347-572 °F (Decomposes) [5] The National Institute for Occupational Safety and Health (NIOSH) - Density
- 1.122 @ 30°C[7]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source – 1.122 at 86 °F (EPA, 1998) - Denser than water [1] CAMEO Chemicalscites U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office. – 1.13 g/cm³ [3] ILO-WHO International Chemical Safety Cards (ICSCs) – 1.12 [4] Occupational Safety and Health Administration (OSHA) –shown 1.122 @ 30°C [7] PAC Chemical Database, U.S. Department of Energy – 1.12 [5] The National Institute for Occupational Safety and Health (NIOSH) - Solubility in water
- Solubility in water, g/100ml at 25 °C: 204 (very good)[3]
4 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source – greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. – In water, 3.711X10+2 g/L at 20 °C; 4.048X10+2 g/L at 30 °C [6] Hazardous Substances Data Bank (HSDB)cites Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 54 –shown Solubility in water, g/100ml at 25 °C: 204 (very good) [3] ILO-WHO International Chemical Safety Cards (ICSCs) – (86 °F): 216% [5] The National Institute for Occupational Safety and Health (NIOSH) - log P
- -0.78[3]
2 values
Sources disagree; from ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative.
Value As written Source – log Kow = -0.67 [6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 6 –shown -0.78 [3] ILO-WHO International Chemical Safety Cards (ICSCs) - Vapor pressure
- Vapor pressure, Pa at 25 °C: 0.9[3]
4 values
2 of 4 sources agree on it (most common value).
Value As written Source 0.007 mmHg 0.007 mmHg at 68 °F (EPA, 1998) [1] CAMEO Chemicalscites U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office. 0.0068 mmHg 0.9 Pa (7X10-3 mm Hg) at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Habermann CE; Acrylamide. Kirk-Othmer Encyclopedia of Chemical Technology. (1999-2016). New York, NY: John Wiley & Sons. Online Posting Date: 16 Aug 2002. 0.0068 mmHgshown Vapor pressure, Pa at 25 °C: 0.9 [3] ILO-WHO International Chemical Safety Cards (ICSCs) 0.007 mmHg 0.007 [mm Hg] @20 °C [7] PAC Chemical Database, U.S. Department of Energy 2 more values were reported but failed the checks (unreadable or out of range), so they are not shown.
- Flash point
- 138.0 °C (280.4 °F, EPA 1998)[1]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source 138.0 °Cshown 280.4 °F (EPA, 1998) [1] CAMEO Chemicalscites U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office. 138 °C 138 °C (280 °F) - closed cup [6] Hazardous Substances Data Bank (HSDB)cites Sigma-Aldrich; Safety Data Sheet for Acrylamide. Product Number: 01700, Version 5.8 (Revision Date 05/27/2016). Available from, as of August 18, 2016: https://www.sigmaaldrich.com/safety-center.html 138 °C 138 °C c.c. [3] ILO-WHO International Chemical Safety Cards (ICSCs) 138 °C 280 °F [4] Occupational Safety and Health Administration (OSHA) 138 °C 280 °F [5] The National Institute for Occupational Safety and Health (NIOSH) - Autoignition temperature
- 240 °C (464 °F)[6]
3 values
2 of 3 sources agree on it (most common value).
Value As written Source 240 °C 464 °F (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office. 240 °Cshown 464 °F (240 °C) [6] Hazardous Substances Data Bank (HSDB)cites National Fire Protection Association; Fire Protection Guide to Hazardous Materials. 14TH Edition, Quincy, MA 2010, p. 49-12 424 °C 424 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs) - Viscosity
- 2.71 cP at 25 °C /50% aqueous solution/[6]
Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.
Calculated
- Heavy atoms
- 5
- Rings
- 0
- Aromatic rings
- 0
- Fraction sp³ carbons (Fsp3)
- 0
- H-bond donors
- 1
- H-bond acceptors
- 1
- Rotatable bonds
- 1
- TPSA (Ų)
- 43.1
- Formal charge
- 0
- XLogP3
- -0.7 PubChem
- Complexity
- 57 PubChem
- Stereocenters
- None
- Double-bond geometry
- None specified
- Point group
- Cs of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)
Elemental analysis
- C50.69%
- H7.09%
- N19.71%
- O22.51%
Isotope pattern
Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.
Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.
Predicted
- log P
- -0.34 Crippen (Wildman and Crippen 1999)
- log S (water solubility)
- 0 ESOL (Delaney 2004), log mol/L
- Synthetic accessibility
- 2.57 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)
Drug-likeness: Lipinski’s rule of five
- Molecular weight ≤ 500: 71.08
- log P ≤ 5 (Crippen): -0.34
- H-bond donors ≤ 5: 1
- H-bond acceptors ≤ 10: 1
Passes all four rules.
¹³C NMR shifts, predicted
Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.
Safety
Danger
Harmonized EU classification (CLP Annex VI). Source [8].
Acute toxicity
Health hazard
- H301Toxic if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H340May cause genetic defects
- H350May cause cancer
Precautionary statements: P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P405, P501
View all classifications (5)
- [8] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH301, H312, H315, H317, H319, H332, H340, H350
- [9] European Chemicals Agency (ECHA)This chemical does not meet GHS hazard criteria for 3.7% (58 of 1562) of reports.
- [9] European Chemicals Agency (ECHA) · 1,562 reports · DangerH301, H312, H315, H317, H319, H332, H340, H350, H361, H372
- [9] European Chemicals Agency (ECHA) · 169 reportsThis chemical does not meet GHS hazard criteria for 100% (169 of 169) of all reports.
- [6] Hazardous Substances Data Bank (HSDB) · DangerH301, H312, H315, H317, H319, H332, H340, H350, H361, H372, H402
Exposure limits
- PEL-TWA (8-Hour Time Weighted Average): 0.3 mg/m³[4]
- PEL: TWA 0.3 mg/m3 [skin] See Appendix G[5]
- REL-TWA (Time Weighted Average): 0.03 mg/m³[4]
- REL: Ca TWA 0.03 mg/m3 [skin] See Appendix A[5]
- TLV: (inhalable fraction and vapour): 0.03 mg/m[3]
- IDLH: 60 mg/m3 ; A potential occupational carcinogen. (NIOSH, 2024)[1]
First aid
- Warning: Effects may be delayed. Caution is advised. Signs and Symptoms of Acute Acrylamide Exposure: Acrylamide is a cumulative neurotoxin. Signs and symptoms of acute exposure may include drowsiness, fatigue, memory loss, confusion, hallucinations, tingling of fingers, loss of vibration and position senses, tremor, muscular weakness, disturbances of balance (especially with the eyes closed), and dysarthria (incoordination of the muscles used for speaking). Excessive sweating of the feet and hands may also occur.[1]
- Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible); polymerization hazard]: Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. Removal of solidified molten material from skin requires medical assistance. (ERG, 2024)[1]
- Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)[1]
- General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[10]
Storage
- Separated from incompatible materials. See Chemical Dangers. Cool. Keep in the dark. Well closed. Store in an area without drain or sewer access.[3]
- Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Store under inert gas. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.[6]
- Separate from oxidizing materials and peroxides. Store in a cool, dry, well-ventilated location. Store away from heat, sunlight, acids, and alkalies.[6]
- Store separately in an area isolated from flammables, combustibles, or other yellow coded materials. ... Store in a secure poison location. ... Store only if stabilized, under inert gas. Before entering confined space where acrylamide may be present, check to make sure that an explosive concentration does not exist. Store in tightly-closed containers in a cool, well-ventilated area. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers.[6]
Incompatibilities
- Incompatible materials: Acids, oxidizing agents, iron and iron salts, copper, brass, free radical initiators.[6]
- Reacts violently with strong oxidizers. Reacts with reducing agents, peroxides, acids, bases, and vinyl polymerization initiators. Fine particles of dust form explosive mixture with air.[6]
- ... Spontaneously reacts with hydroxyl-, amino-, and sulfhydryl-containing compounds.[6]
- Strong oxidizers. [Note: May polymerize violently upon melting.][6]
Safety data sheets on the supplier’s page: Sinfoo Biotech, Shenghe Chemical, Achemtek.
Always read the supplier’s safety data sheet before working with it.
Spectra
- NMRHazardous Substances Data Bank (HSDB) · NMRShiftDB
- 1H NMRHuman Metabolome Database (HMDB) (Bruker · 600 MHz · Water) · SpectraBase (BRUKER AC-300)
- 13C NMRSpectraBase
- 1H-13C NMRHuman Metabolome Database (HMDB) (Bruker · 600 MHz · Water)
- GC-MSHuman Metabolome Database (HMDB) (EI-B · positive) · Human Metabolome Database (HMDB) (EI-B · positive) · Human Metabolome Database (HMDB) (EI-B · positive) · Human Metabolome Database (HMDB) (EI-B · positive) · Human Metabolome Database (HMDB) (EI-B · positive) · Human Metabolome Database (HMDB) (EI-B · positive)
- MS-MSHuman Metabolome Database (HMDB) (Positive) · Human Metabolome Database (HMDB) (Positive) · Human Metabolome Database (HMDB) (Positive) · Human Metabolome Database (HMDB) (Quattro_QQQ · Positive) · Human Metabolome Database (HMDB) (Quattro_QQQ · Positive) · Human Metabolome Database (HMDB) (Quattro_QQQ · Positive)
- LC-MSMassBank of North America (MoNA) (Agilent qTOF 6545 · LC-ESI-QTOF · positive) · MassBank of North America (MoNA) (Thermo Q Exactive HF · LC-ESI-QFT · positive) · MassBank of North America (MoNA) (Agilent qTOF 6545 · LC-ESI-QTOF · positive)
- Other MSHazardous Substances Data Bank (HSDB) · MassBank Europe (Unknown · EI-B · POSITIVE) · MassBank Europe (HITACHI RMU-7M · EI-B · POSITIVE) · MassBank Europe (HITACHI M-60 · EI-B · POSITIVE)
- UVHazardous Substances Data Bank (HSDB)
- IRHazardous Substances Data Bank (HSDB)
- FTIRSpectraBase (FILM (CAST FROM CHLOROFORM))
- ATR-IRSpectraBase (Bio-Rad FTS · ATR-Neat (DurasamplIR II))
- Vapor Phase IRSpectraBase (Bruker IFS 85 · Gas-GC)
- RamanSpectraBase (Bio-Rad FTS 175C with Raman accessory · FT-Raman)
Experimental spectra held by these sources; each link opens the source's own record.
Literature
Reading PubChem, OpenAlex and GSRS…
Bioactivity
Reading ChEMBL…
References
- [1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
- [2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
- [3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [4]Occupational Safety and Health Administration (OSHA) · Public domain (US DOL) · via PubChem · retrieved 2026-10-14
- [5]The National Institute for Occupational Safety and Health (NIOSH) · Public domain (US CDC) · via PubChem · retrieved 2026-10-14
- [6]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
- [7]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
- [8]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [9]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
- [10]Emergency Response Guidebook (ERG) · Public domain (US DOT) · via PubChem · retrieved 2026-10-14
- [11]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
- [12]Human Metabolome Database (HMDB) · Linked only · via PubChem · retrieved 2026-10-14
- [13]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
- [14]MassBank of North America (MoNA) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
- [15]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
- [16]MassBank Europe · Linked only · via PubChem · retrieved 2026-10-14
- ·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
- ·Literature on PubChem
Data last updated 2026-10-14.
