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Tricine

Athanor · official

C6H13NO5 · 179.17 g/mol

IUPAC name: 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid

Also called buffer, SDS-PAGE

Reagents
Open in Athanor
The structure of Tricine
Drawn from its SMILES with RDKit

Names and identifiers

IUPAC name
2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
Synonyms
buffer, SDS-PAGE, N-Tris(hydroxymethyl)methylglycine
+ 37 more

N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine, Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-, W12LH4V8V3, 2-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acid, NSC-369995, 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid, DTXSID1063982, CHEBI:39063, n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine, 2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acid, Glycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-, RefChem:899271, DTXCID6042159, CHEBI:46760, 2-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate, 227-193-6, N-[Tris(hydroxymethyl)methyl]glycine, N-(Tri(hydroxymethyl)methyl)glycine, C6H13NO5, MFCD00004277, NSC 369995, N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]glycine, N-Tris-[hydroxymethyl]methylglycine, AKOS015856413, 2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]acetic acid, n-(tris(hydroxymethyl)methyl)glycine, 2-{[2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]AMINO}ACETIC ACID, {[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonio}acetate, VLS, Tricine, >=98%, AI3-62523, TRICINE [MI], UNII-W12LH4V8V3, SCHEMBL42019, orb3027193, Tricine, >=99% (titration), HY-D0860

Molecular formula
C6H13NO5
Empirical formula
C6H13NO5
Molecular weight
179.17 g/mol
Exact mass
179.07937
CAS number
5704-04-1
PubChem CID
79784
Canonical SMILES
C(C(=O)O)NC(CO)(CO)CO
Isomeric SMILES
C(C(=O)O)NC(CO)(CO)CO
InChI
InChI=1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)
InChIKey
SEQKRHFRPICQDD-UHFFFAOYSA-N
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Calculated

Heavy atoms
12
Rings
0
Aromatic rings
0
Fraction sp³ carbons (Fsp3)
0.83
H-bond donors
5
H-bond acceptors
5 computed here · PubChem 6
Rotatable bonds
6
TPSA (Ų)
110
Formal charge
0
XLogP3
-5.1 PubChem
Complexity
137 PubChem
Stereocenters
None
Double-bond geometry
None specified
Point group
C1 of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

  • C40.22%
  • H7.31%
  • N7.82%
  • O44.65%

Isotope pattern

100%179.0797.2%180.0831.3%181.084

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P
-2.62 Crippen (Wildman and Crippen 1999)
log S (water solubility)
1.1 ESOL (Delaney 2004), log mol/L
Synthetic accessibility
2.86 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

  • Molecular weight ≤ 500: 179.17
  • log P ≤ 5 (Crippen): -2.62
  • H-bond donors ≤ 5: 5
  • H-bond acceptors ≤ 10: 5

Passes all four rules.

¹³C NMR shifts, predicted

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.[1]

Safety data sheets on the supplier’s page: Biosynth, Thermo Fisher Scientific, AgroIntelBioScan.com.

Always read the supplier’s safety data sheet before working with it.

Spectra

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

  1. [1]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
  2. [2]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
  3. [3]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
  4. ·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
  5. ·Literature on PubChem

Data last updated 2026-10-14.