1,4-Dioxane

Athanor · official

C₄H₈O₂ · 88.11 g/mol

Also called dioxane, diethylene dioxide, p-dioxane

Solvents Rings

Open in Athanor

Drawn from its SMILES with RDKit

DangerHighly Flammable liquid and vapor · Causes serious eye irritation · May cause respiratory irritation · May cause cancer

Names and identifiers

IUPAC name: 1,4-dioxane
Synonyms: dioxane, diethylene dioxide, p-dioxane
+ 38 more
Dioxane, p-Dioxane, Diethylene ether, 1,4-Diethylene dioxide, 1,4-Dioxacyclohexane, Dioxan, Tetrahydro-1,4-dioxin, Tetrahydro-p-dioxin, Di(ethylene oxide), Diethylene dioxide, Dioxanne, Dioxane-1,4, 1,4-Dioxan, Glycol ethylene ether, Dioxan-1,4, p-Dioxan, Tetrahydro-para-dioxin, Dioxyethylene ether, Dioksan, Diokan, para-Dioxane, Diossano-1,4, Dioxaan-1,4, Glycolethylenether, p-Dioxin, tetrahydro-, 1,4-Dioxanne, RCRA waste number U108, 1,4-Diethyleneoxide, NCI-C03689, Dioxane, technical grade, DTXSID4020533, NE 220, J8A3S10O7S, NSC-8728, DTXCID00533, CHEBI:47032, NSC8728, 1,4 Diethylene Ether
Molecular formula: C₄H₈O₂
Empirical formula: C₂H₄O
Molecular weight: 88.11 g/mol
Exact mass: 88.05243
CAS number: 123-91-1
PubChem CID: 31275
Canonical SMILES: C1COCCO1
Isomeric SMILES: C1COCCO1
InChI: InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
InChIKey: RYHBNJHYFVUHQT-UHFFFAOYSA-N
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Physical properties

TemperaturePressureDensity

Appearance: Colorless liquid or solid (below 53 degrees F)[6]
6 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
– Dioxane appears as a clear colorless liquid with a faint ethereal odor. Flash point 55 °F. Slightly denser than water and soluble in water. Vapors heavier than air. Susceptible to autooxidation to form peroxides. [1] CAMEO Chemicals
– Liquid; Other Solid; Liquid [2] EPA Chemical Data Reporting (CDR)
– COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– Colorless liquid or solid (below 53 °F) with a mild, ether-like odor. [4] Occupational Safety and Health Administration (OSHA)
– Colorless liquid or solid (below 53 °F) with a mild, ether-like odor. [5] The National Institute for Occupational Safety and Health (NIOSH)
–shown Colorless liquid or solid (below 53 degrees F) [6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg
Odor: Mild, ether-like odor[6]
2 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
–shown Mild, ether-like odor [6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg
– The odor of dioxane in low concentrations is faint and generally inoffensive and has been described as being somewhat alcoholic. [6] Hazardous Substances Data Bank (HSDB)cites Cragg ST; Ethers of Ethylene Glycol and Derivatives. Patty's Toxicology. 6th ed. (1999-2015). New York, NY: John Wiley & Sons, Inc. On-line Posting Date: Aug 17, 2012.
Melting point: 11.7 °C[7]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source
11.8 °C 53.2 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
12 °C 12 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
12 °C 53 °F [4] Occupational Safety and Health Administration (OSHA)
11.7 °Cshown 11.7 °C [7] PAC Chemical Database, U.S. Department of Energy
12 °C 53 °F [5] The National Institute for Occupational Safety and Health (NIOSH)
Boiling point: 101.5 °C @760 [mmHg][7]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source
101 °C 214 °F at 760 mmHg (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
101 °C 101 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
101 °C 214 °F [4] Occupational Safety and Health Administration (OSHA)
101.5 °Cshown 101.5 °C @760 [mm Hg] [7] PAC Chemical Database, U.S. Department of Energy
101 °C 214 °F [5] The National Institute for Occupational Safety and Health (NIOSH)
Density: 1.0337 @ 20°C[7]
5 values
5 of 5 sources agree on it (most common value).
Value As written Source
– 1.036 at 68 °F (USCG, 1999) - Denser than water [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
– Relative density (water = 1): 1.03 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– 1.03 [4] Occupational Safety and Health Administration (OSHA)
–shown 1.0337 @ 20°C [7] PAC Chemical Database, U.S. Department of Energy
– 1.03 [5] The National Institute for Occupational Safety and Health (NIOSH)
Solubility in water: Solubility in water: miscible[3]
6 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source
– greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
– In water, >800 g/L at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 118
– Miscible with most organic solvents [6] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 461
– Miscible with aromatic hydrocarbons and oils. [6] Hazardous Substances Data Bank (HSDB)cites USEPA; Chemical Hazard Information Profile: 1,4-Dioxane (Draft) p.1 (1979)
–shown Solubility in water: miscible [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– Miscible [5] The National Institute for Occupational Safety and Health (NIOSH)
log P: -0.27[3]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source
– log Kow = -0.27 [6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 8
–shown -0.27 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
Vapor pressure: 38.1 mmHg at 25 °C[6]
5 values
2 of 4 sources agree on it (most common value).
Value As written Source
29 mmHg 29 mmHg at 68 °F [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
37 mmHg 37 mmHg at 77 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
38.1 mmHgshown 38.1 mm Hg at 25 °C [6] Hazardous Substances Data Bank (HSDB)cites Daubert, T.E., R.P. Danner. Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, D.C.: Taylor and Francis, 1989.
29 mmHg Vapor pressure, kPa at 20 °C: 3.9 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
75 mmHg 75 [mm Hg] @39.6 °C [7] PAC Chemical Database, U.S. Department of Energy
2 more values were reported but failed the checks (unreadable or out of range), so they are not shown.
Flash point: 12 °C c.c.[3]
5 values
4 of 5 sources agree on it (most common value).
Value As written Source
12 °C 54 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
18.3 °C 65 °F (18.3 °C) (Open cup) [6] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 461
12 °Cshown 12 °C c.c. [3] ILO-WHO International Chemical Safety Cards (ICSCs)
13 °C 55 °F [4] Occupational Safety and Health Administration (OSHA)
13 °C 55 °F [5] The National Institute for Occupational Safety and Health (NIOSH)
Autoignition temperature: 180 °C[3]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source
180 °C 356 °F (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
180 °Cshown 180 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
1 more value was reported but failed the checks (unreadable or out of range), so it is not shown.
Viscosity: Reported, but no value passed the checks.
The value and why
1.17 mm²/s at 25 °C (could not be read; source [3])

Value	As written	Source
–	Dioxane appears as a clear colorless liquid with a faint ethereal odor. Flash point 55 °F. Slightly denser than water and soluble in water. Vapors heavier than air. Susceptible to autooxidation to form peroxides.	[1] CAMEO Chemicals
–	Liquid; Other Solid; Liquid	[2] EPA Chemical Data Reporting (CDR)
–	COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	Colorless liquid or solid (below 53 °F) with a mild, ether-like odor.	[4] Occupational Safety and Health Administration (OSHA)
–	Colorless liquid or solid (below 53 °F) with a mild, ether-like odor.	[5] The National Institute for Occupational Safety and Health (NIOSH)
–shown	Colorless liquid or solid (below 53 degrees F)	[6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg

Value	As written	Source
–shown	Mild, ether-like odor	[6] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg
–	The odor of dioxane in low concentrations is faint and generally inoffensive and has been described as being somewhat alcoholic.	[6] Hazardous Substances Data Bank (HSDB)cites Cragg ST; Ethers of Ethylene Glycol and Derivatives. Patty's Toxicology. 6th ed. (1999-2015). New York, NY: John Wiley & Sons, Inc. On-line Posting Date: Aug 17, 2012.

Value	As written	Source
11.8 °C	53.2 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
12 °C	12 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
12 °C	53 °F	[4] Occupational Safety and Health Administration (OSHA)
11.7 °Cshown	11.7 °C	[7] PAC Chemical Database, U.S. Department of Energy
12 °C	53 °F	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
101 °C	214 °F at 760 mmHg (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
101 °C	101 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
101 °C	214 °F	[4] Occupational Safety and Health Administration (OSHA)
101.5 °Cshown	101.5 °C @760 [mm Hg]	[7] PAC Chemical Database, U.S. Department of Energy
101 °C	214 °F	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	1.036 at 68 °F (USCG, 1999) - Denser than water	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
–	Relative density (water = 1): 1.03	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	1.03	[4] Occupational Safety and Health Administration (OSHA)
–shown	1.0337 @ 20°C	[7] PAC Chemical Database, U.S. Department of Energy
–	1.03	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–	In water, >800 g/L at 25 °C	[6] Hazardous Substances Data Bank (HSDB)cites Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 118
–	Miscible with most organic solvents	[6] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 461
–	Miscible with aromatic hydrocarbons and oils.	[6] Hazardous Substances Data Bank (HSDB)cites USEPA; Chemical Hazard Information Profile: 1,4-Dioxane (Draft) p.1 (1979)
–shown	Solubility in water: miscible	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	Miscible	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	log Kow = -0.27	[6] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 8
–shown	-0.27	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
29 mmHg	29 mmHg at 68 °F	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
37 mmHg	37 mmHg at 77 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
38.1 mmHgshown	38.1 mm Hg at 25 °C	[6] Hazardous Substances Data Bank (HSDB)cites Daubert, T.E., R.P. Danner. Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, D.C.: Taylor and Francis, 1989.
29 mmHg	Vapor pressure, kPa at 20 °C: 3.9	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
75 mmHg	75 [mm Hg] @39.6 °C	[7] PAC Chemical Database, U.S. Department of Energy

Value	As written	Source
12 °C	54 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
18.3 °C	65 °F (18.3 °C) (Open cup)	[6] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 461
12 °Cshown	12 °C c.c.	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
13 °C	55 °F	[4] Occupational Safety and Health Administration (OSHA)
13 °C	55 °F	[5] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
180 °C	356 °F (USCG, 1999)	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
180 °Cshown	180 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.

Calculated

Heavy atoms: 6
Rings: 1
Aromatic rings: 0
Fraction sp³ carbons (Fsp3): 1
H-bond donors: 0
H-bond acceptors: 2
Rotatable bonds: 0
TPSA (Å²): 18.5
Formal charge: 0
XLogP3: -0.3 PubChem
Complexity: 26 PubChem
Stereocenters: None
Double-bond geometry: None specified
Point group: C2h of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

C54.53%
H9.15%
O36.32%

Isotope pattern

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P: 0.03 Crippen (Wildman and Crippen 1999)
log S (water solubility): -0.41 ESOL (Delaney 2004), log mol/L
Synthetic accessibility: 2.23 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

Molecular weight ≤ 500: 88.11
log P ≤ 5 (Crippen): 0.03
H-bond donors ≤ 5: 0
H-bond acceptors ≤ 10: 2

Passes all four rules.

¹³C NMR shifts, predicted

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

Danger

Harmonized EU classification (CLP Annex VI). Source [8].

Flammable
Harmful or irritant
Health hazard

NFPA 704[6]

H225Highly Flammable liquid and vapor
H319Causes serious eye irritation
H335May cause respiratory irritation
H350May cause cancer

Precautionary statements: P203, P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, P501

View all classifications (3)

[8] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH225, H319, H335, H350
[9] European Chemicals Agency (ECHA) · 1,577 reports · DangerH225, H319, H350, H351
[6] Hazardous Substances Data Bank (HSDB) · DangerH225, H319, H335, H351

Exposure limits

PEL-TWA (8-Hour Time Weighted Average): 100 ppm (360 mg/m³)[4]
PEL: TWA 100 ppm (360 mg/m3) [skin] See Appendix G[5]
REL-C (Ceiling): 1 ppm (3.6 mg/m³) [30 minutes][4]
REL: Ca C 1 ppm (3.6 mg/m3) [30-minute] See Appendix A[5]
TLV: 20 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).[3]
TLV-TWA (Time Weighted Average): 20 ppm [1996][4]

First aid

Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]
General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[10]
(General first aid procedures) Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Skin: Water wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with water. If irritation persists after washing, get medical attention. Breathing: Respiratory support Swallow: Medical attention immediately - If this[5]
Fresh air, rest. Refer immediately for medical attention.[3]

Storage

Fireproof. Separated from strong oxidants, strong acids and incompatible materials. Cool. Dry. Well closed. Keep in the dark. Store only if stabilized. Store in an area without drain or sewer access.[3]
Store in a cool, dry, well-ventilated location. Store away from heat, oxidizing materials, and sunlight. Outside or detached storage is preferred. Inside storage should be in a standard flammable liquids storage warehouse, room, or cabinet.[6]
Precautions FOR "carcinogens": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... Expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... Should be kept, showing quantity of carcinogen and date it was acquired ... Facilities for dispensing ... Should be contiguous to storage area. (chemical Carcinogens)[6]
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids[6]

Incompatibilities

Pure, dry, o- and hydroperoxide-free dioxane rapidly forms hydroperoxide on contact with air.[6]
Decaborane ... Forms impact sensitive mixtures with ... Dioxane. ...[6]
Since 1:1 addition (of sulfur trioxide-dioxane) complex sometimes decomposes violently on storing at ambient temp, it should be prepared immediately before use (if refrigerated storage is not possible).[6]
(in the reaction with triethynylaluminium) the residue from sublimation of the complex with dioxane is explosive, and the complex should not be dried by heating.[6]

Safety data sheets on the supplier’s page: Thermo Fisher Scientific, LGC Standards, Sigma-Aldrich.

Always read the supplier’s safety data sheet before working with it.

Spectra

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

[1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
[2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
[3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[4]Occupational Safety and Health Administration (OSHA) · Public domain (US DOL) · via PubChem · retrieved 2026-10-14
[5]The National Institute for Occupational Safety and Health (NIOSH) · Public domain (US CDC) · via PubChem · retrieved 2026-10-14
[6]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
[7]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
[8]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
[9]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
[10]Emergency Response Guidebook (ERG) · Public domain (US DOT) · via PubChem · retrieved 2026-10-14
[11]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
[12]Human Metabolome Database (HMDB) · Linked only · via PubChem · retrieved 2026-10-14
[13]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
[14]MassBank of North America (MoNA) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[15]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
[16]MassBank Europe · Linked only · via PubChem · retrieved 2026-10-14
·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
·Literature on PubChem

Data last updated 2026-10-14.