Sodium fluoride

Athanor · official

FNa · 41.9881724 g/mol

Also called fluoride, E554

Inorganic

Open in Athanor

Drawn from its SMILES with RDKit

DangerToxic if swallowed · Causes skin irritation · Causes serious eye irritation

Names and identifiers

IUPAC name: sodium fluoride
Synonyms: fluoride, E554, Sodium fluoride (NaF)
+ 37 more
Fluoride, sodium, Florocid, Pergantene, Zymafluor, Pediaflor, Ossin, Sodium flouride, Fluonatril, Fluorident, Sodium monofluoride, Villiaumite, Antibulit, Floridine, Fluoraday, Fluorol, Flursol, Karidium, Koreberon, Liquiflur, Ossalin, Xaridium, Flura, Luride, Roach salt, Flura Drops, T-Fluoride, Fungol B, Sodium hydrofluoride, Chemifluor, Flozenges, Fluorigard, Fluorineed, Fluorinse, Fluoritab, Fluorocid, Flurcare, Gelution
Molecular formula: FNa
Empirical formula: FNa
Molecular weight: 41.9881724 g/mol
Exact mass: 41.98817
CAS number: 7681-49-4
PubChem CID: 5235
Canonical SMILES: [F-].[Na+]
Isomeric SMILES: [F-].[Na+]
InChI: InChI=1S/FH.Na/h1H;/q;+1/p-1
InChIKey: PUZPDOWCWNUUKD-UHFFFAOYSA-M
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Physical properties

TemperaturePressureDensity

Appearance: White powder or colorless crystals [Note: Pesticide grade is often dyed blue].[5]
6 values
From Hazardous Substances Data Bank (HSDB), the most authoritative source here.
Value As written Source
– Sodium fluoride is a colorless crystalline solid or white powder, or the solid dissolved in a liquid. It is soluble in water. It is noncombustible. It is corrosive to aluminum. It is used as an insecticide. It is also used to fluorinate water supplies, as a wood preservative, in cleaning compounds, manufacture of glass, and for many other uses. [1] CAMEO Chemicals
– Sodium fluoride, solution appears as an aqueous solution. Odorless. The maximum solubility of sodium fluoride in water at room temperature is 4.2 g per 100 g of water. [1] CAMEO Chemicals
– Dry Powder; Large Crystals; Liquid; Other Solid [2] EPA Chemical Data Reporting (CDR)
– WHITE CRYSTALS OR POWDER. [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– Odorless, white powder or colorless crystals. [Note: Pesticide grade is often dyed blue.] [4] The National Institute for Occupational Safety and Health (NIOSH)
–shown White powder or colorless crystals [Note: Pesticide grade is often dyed blue]. [5] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)
Odor: Odorless[5]
Melting point: 993 °C (1819 °F, NTP 1992)[1]
4 values
3 of 4 sources agree on it (most common value).
Value As written Source
993 °Cshown 1819 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
993 °C 993 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
996 °C 996 °C [6] PAC Chemical Database, U.S. Department of Energy
993 °C 1819 °F [4] The National Institute for Occupational Safety and Health (NIOSH)
Boiling point: 1704 °C @760 [mmHg][6]
4 values
2 of 4 sources agree on it (most common value).
Value As written Source
1695 °C 3083 °F at 760 mmHg (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
1700 °C 1700 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
1704 °Cshown 1704 °C @760 [mm Hg] [6] PAC Chemical Database, U.S. Department of Energy
1704 °C 3099 °F [4] The National Institute for Occupational Safety and Health (NIOSH)
Density: 2.78 @25 °C[6]
4 values
4 of 4 sources agree on it (most common value).
Value As written Source
– 2.79 at 68 °F (USCG, 1999) - Denser than water [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
– 2.8 g/cm³ [3] ILO-WHO International Chemical Safety Cards (ICSCs)
–shown 2.78 @25 °C [6] PAC Chemical Database, U.S. Department of Energy
– 2.78 [4] The National Institute for Occupational Safety and Health (NIOSH)
Solubility in water: Solubility in water, g/100ml at 20 °C: 4.0[3]
3 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source
– 10 to 50 mg/mL at 73 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–shown Solubility in water, g/100ml at 20 °C: 4.0 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– 4% [4] The National Institute for Occupational Safety and Health (NIOSH)
Vapor pressure: VP: 1 mmHg at 1077 °C[5]
3 values
2 of 2 sources agree on it (most common value).
Value As written Source
1 mmHg 1 mmHg at 1971 °F [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
5 mmHg 5 mmHg at 2167 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
1 mmHgshown VP: 1 mm Hg at 1077 °C [5] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 10th ed. Volumes 1-3 New York, NY: John Wiley & Sons Inc., 1999., p. 3248
1 more value was reported but failed the checks (unreadable or out of range), so it is not shown.
Autoignition temperature: Reported, but no value passed the checks.
The value and why
Not flammable (USCG, 1999) (could not be read; source [1])

Value	As written	Source
–	Sodium fluoride is a colorless crystalline solid or white powder, or the solid dissolved in a liquid. It is soluble in water. It is noncombustible. It is corrosive to aluminum. It is used as an insecticide. It is also used to fluorinate water supplies, as a wood preservative, in cleaning compounds, manufacture of glass, and for many other uses.	[1] CAMEO Chemicals
–	Sodium fluoride, solution appears as an aqueous solution. Odorless. The maximum solubility of sodium fluoride in water at room temperature is 4.2 g per 100 g of water.	[1] CAMEO Chemicals
–	Dry Powder; Large Crystals; Liquid; Other Solid	[2] EPA Chemical Data Reporting (CDR)
–	WHITE CRYSTALS OR POWDER.	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	Odorless, white powder or colorless crystals. [Note: Pesticide grade is often dyed blue.]	[4] The National Institute for Occupational Safety and Health (NIOSH)
–shown	White powder or colorless crystals [Note: Pesticide grade is often dyed blue].	[5] Hazardous Substances Data Bank (HSDB)cites NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases CD-ROM. Department of Health & Human Services, Centers for Disease Prevention & Control. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No. 2005-151 (2005)

Value	As written	Source
993 °Cshown	1819 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
993 °C	993 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
996 °C	996 °C	[6] PAC Chemical Database, U.S. Department of Energy
993 °C	1819 °F	[4] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
1695 °C	3083 °F at 760 mmHg (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
1700 °C	1700 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
1704 °Cshown	1704 °C @760 [mm Hg]	[6] PAC Chemical Database, U.S. Department of Energy
1704 °C	3099 °F	[4] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	2.79 at 68 °F (USCG, 1999) - Denser than water	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
–	2.8 g/cm³	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–shown	2.78 @25 °C	[6] PAC Chemical Database, U.S. Department of Energy
–	2.78	[4] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
–	10 to 50 mg/mL at 73 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–shown	Solubility in water, g/100ml at 20 °C: 4.0	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	4%	[4] The National Institute for Occupational Safety and Health (NIOSH)

Value	As written	Source
1 mmHg	1 mmHg at 1971 °F	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
5 mmHg	5 mmHg at 2167 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
1 mmHgshown	VP: 1 mm Hg at 1077 °C	[5] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 10th ed. Volumes 1-3 New York, NY: John Wiley & Sons Inc., 1999., p. 3248

Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.

Calculated

Heavy atoms: 2
Rings: 0
Aromatic rings: 0
Fraction sp³ carbons (Fsp3): 0
H-bond donors: 0
H-bond acceptors: 0 computed here · PubChem 1
Rotatable bonds: 0
TPSA (Å²): 0
Formal charge: 0
Complexity: 2 PubChem
Stereocenters: None
Double-bond geometry: None specified
Point group: Kh of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

F45.25%
Na54.75%

Isotope pattern

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P: -5.99 Crippen (Wildman and Crippen 1999)
log S (water solubility): 3.67 ESOL (Delaney 2004), log mol/L
Synthetic accessibility: 8.49 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

Molecular weight ≤ 500: 41.99
log P ≤ 5 (Crippen): -5.99
H-bond donors ≤ 5: 0
H-bond acceptors ≤ 10: 0

Passes all four rules.

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

Danger

Harmonized EU classification (CLP Annex VI). Source [7].

Acute toxicity

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264+P265, P270, P280, P301+P316, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, P405, P501

View all classifications (3)

[7] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH301, H315, H319
[8] European Chemicals Agency (ECHA)This chemical does not meet GHS hazard criteria for 1.8% (11 of 623) of reports.
[8] European Chemicals Agency (ECHA) · 623 reports · DangerH301, H315, H319

Exposure limits

PEL: TWA 2.5 mg/m3 [*Note: The PEL also applies to other inorganic, solid fluorides (as F).][4]
REL: TWA 2.5 mg/m3 [*Note: The REL also applies to other inorganic, solid fluorides (as F).][4]
TLV: (as F): 2.5 mg/m[3]
IDLH: 250 mg F/m3 (NIOSH, 2024)[1]
IDLH: 250 mg/cu m (as F)[5]
IDLH: 250 mg/m3 (as F) See: Fluoride[4]

First aid

Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. (ERG, 2024)[1]
General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[9]
General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[9]

Storage

Separated from acids and food and feedstuffs.[3]
Aqueous solutions of sodium fluoride slowly decompose and become alkaline when stored in glass. Therefore, sodium fluoride solutions should be stored in tight, plastic containers, especially if the pH of the solution is less than 7.5. Sodium fluoride solutions and tablets should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing of the solutions should be avoided. Sodium fluoride is incompatible with calcium and magnesium salts.[5]
Store in a cool, dry, well-ventilated location. Separate from acids and alkalies.[5]
Sodium fluoride (container) ... Should be colored to help distinguish it from table salt or flour.[5]

Incompatibilities

Strong oxidizers.[5]
Reacts with acids to form hydrogen fluoride.[5]
Strong oxidizers[4]

Safety data sheets on the supplier’s page: Oakwood Products, AEZ Kimya, Clearsynth.

Always read the supplier’s safety data sheet before working with it.

Spectra

RamanRRUFF Project

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

[1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
[2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
[3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[4]The National Institute for Occupational Safety and Health (NIOSH) · Public domain (US CDC) · via PubChem · retrieved 2026-10-14
[5]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
[6]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
[7]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
[8]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
[9]Emergency Response Guidebook (ERG) · Public domain (US DOT) · via PubChem · retrieved 2026-10-14
[10]RRUFF Project · Linked only · via PubChem · retrieved 2026-10-14
·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
·Literature on PubChem

Data last updated 2026-10-14.