1,2-Dimethoxyethane

Athanor · official

C₄H₁₀O₂ · 90.12 g/mol

Also called DME, glyme, monoglyme, ethylene glycol dimethyl ether

Solvents

Open in Athanor

Drawn from its SMILES with RDKit

DangerHighly Flammable liquid and vapor · Harmful if inhaled · May damage fertility; May damage the unborn child

Names and identifiers

IUPAC name: 1,2-dimethoxyethane
Synonyms: DME, glyme, monoglyme
+ 39 more
ethylene glycol dimethyl ether, Monoglyme, Ethylene glycol dimethyl ether, Glyme, Dimethyl Cellosolve, Dimethoxyethane, Egdme, 2,5-Dioxahexane, Ethane, 1,2-dimethoxy-, Glycol dimethyl ether, Dimethylcellosolve, Hisolve MMM, Ethylene dimethyl ether, Ansul ether 121, DME (glycol ether), Monoethylene glycol dimethyl ether, DTXSID0025286, alpha,beta-Dimethoxyethane, GXS24JF5IW, NSC-60542, DTXCID705286, CHEBI:42263, GDME, RefChem:71965, 1,2-Ethanediol, dimethyl ether, 203-794-9, Dimethylglycol, Dimethyl Glycol, 1,2-Dimethoxyethan, mono-Glyme, 1,2-Ethanediol dimethyl ether, CH3OCH2CH2OCH3, .alpha.,.beta.-Dimethoxyethane, Ethylenglycoldimethylether, Ethylenglykoldimethylether, MFCD00008502, NSC 60542, 1,2-dimethoxy-ethane, 1,2-DIMETHYLCYCLOHEXANE, ETHYLENE GLYCOL DIMETHYL ETHER
Molecular formula: C₄H₁₀O₂
Empirical formula: C₂H₅O
Molecular weight: 90.12 g/mol
Exact mass: 90.06808
CAS number: 110-71-4
PubChem CID: 8071
Canonical SMILES: COCCOC
Isomeric SMILES: COCCOC
InChI: InChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
InChIKey: XTHFKEDIFFGKHM-UHFFFAOYSA-N
Molfile

Names, InChI and the identifiers from PubChem, retrieved 2026-10-14.

Physical properties

TemperaturePressureDensity

Appearance: 1,2-dimethoxyethane appears as a liquid with a sharp odor. Less dense than water. Flash point 1 °C (34 °F). Mildly toxic by ingestion and inhalation. Severely irritates skin and eyes. Vapors heavier than air. Used to make other chemicals.[1]
5 values
From CAMEO Chemicals, the most authoritative source here.
Value As written Source
–shown 1,2-dimethoxyethane appears as a liquid with a sharp odor. Less dense than water. Flash point 34 °F. Mildly toxic by ingestion and inhalation. Severely irritates skin and eyes. Vapors heavier than air. Used to make other chemicals. [1] CAMEO Chemicals
– Liquid; Gas Vapor [2] EPA Chemical Data Reporting (CDR)
– COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. [3] ILO-WHO International Chemical Safety Cards (ICSCs)
– WATER-WHITE LIQUID [4] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 488
– COLORLESS LIQUID [4] Hazardous Substances Data Bank (HSDB)cites Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 398
Odor: Mild odor[4]
Melting point: -58 °C[3]
3 values
2 of 3 sources agree on it (most common value).
Value As written Source
−58 °C -72 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−58 °Cshown -58 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
−69.2 °C -69.2 °C [5] PAC Chemical Database, U.S. Department of Energy
Boiling point: 85 °C (185 °F) at 760 mmHg (NTP, 1992)[1]
2 values
Sources disagree; from CAMEO Chemicals, the most authoritative.
Value As written Source
85 °Cshown 185 °F at 760 mmHg (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
82 to 83 °C 82-83 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)
Density: 0.86877 @25 °C[5]
3 values
3 of 3 sources agree on it (most common value).
Value As written Source
– 0.868 at 68 °F (USCG, 1999) - Less dense than water [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
– Relative density (water = 1): 0.86 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
–shown 0.86877 @25 °C [5] PAC Chemical Database, U.S. Department of Energy
Solubility in water: Solubility in water: miscible[3]
3 values
From ILO-WHO International Chemical Safety Cards (ICSCs), the most authoritative source here.
Value As written Source
– greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
– water solubility = 1.00X10+6 mg/l @ 25 °C [4] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985.
–shown Solubility in water: miscible [3] ILO-WHO International Chemical Safety Cards (ICSCs)
log P: -0.21[3]
2 values
2 of 2 sources agree on it (most common value).
Value As written Source
– Log Kow = -0.21 [4] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 10
–shown -0.21 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
Vapor pressure: Vapor pressure, kPa at 20 °C: 6.4[3]
5 values
3 of 4 sources agree on it (most common value).
Value As written Source
40 mmHg 40 mmHg at 51.3 °F [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
60 mmHg 60 mmHg at 67.5 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
48 mmHg 48 MM HG @ 20 °C [4] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 296
48 mmHgshown Vapor pressure, kPa at 20 °C: 6.4 [3] ILO-WHO International Chemical Safety Cards (ICSCs)
48 mmHg 48 [mm Hg] @20 °C [5] PAC Chemical Database, U.S. Department of Energy
Flash point: -2 °C c.c.[3]
3 values
2 of 3 sources agree on it (most common value).
Value As written Source
0 °C 32 °F (NTP, 1992) [1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−2 °C 29 °F(-2 °C) (CLOSED CUP) [4] Hazardous Substances Data Bank (HSDB)cites Fire Protection Guide to Hazardous Materials. 12 ed. Quincy, MA: National Fire Protection Association, 1997., p. 325-51
−2 °Cshown -2 °C c.c. [3] ILO-WHO International Chemical Safety Cards (ICSCs)
Autoignition temperature: 202 °C[3]
3 values
3 of 3 sources agree on it (most common value).
Value As written Source
202 °C 395 °F (USCG, 1999) [1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
202 °C 395 °F (202 °C) [4] Hazardous Substances Data Bank (HSDB)cites Fire Protection Guide to Hazardous Materials. 12 ed. Quincy, MA: National Fire Protection Association, 1997., p. 325-51
202 °Cshown 202 °C [3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
–shown	1,2-dimethoxyethane appears as a liquid with a sharp odor. Less dense than water. Flash point 34 °F. Mildly toxic by ingestion and inhalation. Severely irritates skin and eyes. Vapors heavier than air. Used to make other chemicals.	[1] CAMEO Chemicals
–	Liquid; Gas Vapor	[2] EPA Chemical Data Reporting (CDR)
–	COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–	WATER-WHITE LIQUID	[4] Hazardous Substances Data Bank (HSDB)cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 488
–	COLORLESS LIQUID	[4] Hazardous Substances Data Bank (HSDB)cites Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 398

Value	As written	Source
−58 °C	-72 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−58 °Cshown	-58 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
−69.2 °C	-69.2 °C	[5] PAC Chemical Database, U.S. Department of Energy

Value	As written	Source
85 °Cshown	185 °F at 760 mmHg (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
82 to 83 °C	82-83 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
–	0.868 at 68 °F (USCG, 1999) - Less dense than water	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
–	Relative density (water = 1): 0.86	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
–shown	0.86877 @25 °C	[5] PAC Chemical Database, U.S. Department of Energy

Value	As written	Source
–	greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
–	water solubility = 1.00X10+6 mg/l @ 25 °C	[4] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985.
–shown	Solubility in water: miscible	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
–	Log Kow = -0.21	[4] Hazardous Substances Data Bank (HSDB)cites Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 10
–shown	-0.21	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
40 mmHg	40 mmHg at 51.3 °F	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
60 mmHg	60 mmHg at 67.5 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
48 mmHg	48 MM HG @ 20 °C	[4] Hazardous Substances Data Bank (HSDB)cites Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 296
48 mmHgshown	Vapor pressure, kPa at 20 °C: 6.4	[3] ILO-WHO International Chemical Safety Cards (ICSCs)
48 mmHg	48 [mm Hg] @20 °C	[5] PAC Chemical Database, U.S. Department of Energy

Value	As written	Source
0 °C	32 °F (NTP, 1992)	[1] CAMEO Chemicalscites National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
−2 °C	29 °F(-2 °C) (CLOSED CUP)	[4] Hazardous Substances Data Bank (HSDB)cites Fire Protection Guide to Hazardous Materials. 12 ed. Quincy, MA: National Fire Protection Association, 1997., p. 325-51
−2 °Cshown	-2 °C c.c.	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Value	As written	Source
202 °C	395 °F (USCG, 1999)	[1] CAMEO Chemicalscites U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
202 °C	395 °F (202 °C)	[4] Hazardous Substances Data Bank (HSDB)cites Fire Protection Guide to Hazardous Materials. 12 ed. Quincy, MA: National Fire Protection Association, 1997., p. 325-51
202 °Cshown	202 °C	[3] ILO-WHO International Chemical Safety Cards (ICSCs)

Each value as its source reports it, with the source's number after it (listed under References). Where several sources report a property, the row shows the value most of them agree on, the rule the app uses; open the values to see every one.

Calculated

Heavy atoms: 6
Rings: 0
Aromatic rings: 0
Fraction sp³ carbons (Fsp3): 1
H-bond donors: 0
H-bond acceptors: 2
Rotatable bonds: 3
TPSA (Å²): 18.5
Formal charge: 0
XLogP3: -0.2 PubChem
Complexity: 17 PubChem
Stereocenters: None
Double-bond geometry: None specified
Point group: C1 of one 3D conformer with its hydrogens, by Athanor’s engine (as in the app)

Elemental analysis

C53.31%
H11.18%
O35.51%

Isotope pattern

Each peak is a nominal mass with its abundance-weighted exact mass, as a percentage of the tallest, from IUPAC natural isotope abundances.

Computed from the structure with RDKit 2026.09 when this page was built, beside PubChem's own computed values from its record; where the two differ, both are shown.

Predicted

log P: 0.28 Crippen (Wildman and Crippen 1999)
log S (water solubility): -0.38 ESOL (Delaney 2004), log mol/L
Synthetic accessibility: 1.66 SA score, 1 easy to 10 hard (Ertl and Schuffenhauer 2009)

Drug-likeness: Lipinski’s rule of five

Molecular weight ≤ 500: 90.12
log P ≤ 5 (Crippen): 0.28
H-bond donors ≤ 5: 0
H-bond acceptors ≤ 10: 2

Passes all four rules.

¹³C NMR shifts, predicted

Predictions, not measurements; each names its method. A measured log P, where a source reports one, is under Physical properties.

Safety

Danger

Harmonized EU classification (CLP Annex VI). Source [6].

Flammable
Harmful or irritant
Health hazard

NFPA 704[4]

H225Highly Flammable liquid and vapor
H332Harmful if inhaled
H360FDMay damage fertility; May damage the unborn child

Precautionary statements: P203, P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P317, P318, P370+P378, P403+P235, P405, P501

View all classifications (3)

[6] Regulation (EC) No 1272/2008 of the European Parliament and of the Council · DangerH225, H332, H360FD
[7] European Chemicals Agency (ECHA)This chemical does not meet GHS hazard criteria for 0.2% (1 of 640) of reports.
[7] European Chemicals Agency (ECHA) · 640 reports · DangerH225, H315, H332, H351, H360, H360FD

First aid

Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing.[1]
General First Aid: · Call 911 or emergency medical service. · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination. · Move victim to fresh air if it can be done safely. · Administer oxygen if breathing is difficult. · If victim is not breathing: -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance. -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped…[8]
Fresh air, rest.[3]
Remove contaminated clothes. Rinse skin with plenty of water or shower.[3]

Storage

Cool. Fireproof. Separated from strong oxidants.[3]

Safety data sheets on the supplier’s page: Yuhao Chemical, eMolecules, MuseChem.

Always read the supplier’s safety data sheet before working with it.

Spectra

Experimental spectra held by these sources; each link opens the source's own record.

Literature

Reading PubChem, OpenAlex and GSRS…

Bioactivity

Reading ChEMBL…

References

[1]CAMEO Chemicals · Public domain (NOAA) · via PubChem · retrieved 2026-10-14
[2]EPA Chemical Data Reporting (CDR) · Public domain (US EPA) · via PubChem · retrieved 2026-10-14
[3]ILO-WHO International Chemical Safety Cards (ICSCs) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[4]Hazardous Substances Data Bank (HSDB) · Public domain (US NLM) · via PubChem · retrieved 2026-10-14
[5]PAC Chemical Database, U.S. Department of Energy · Public domain (US DOE) · via PubChem · retrieved 2026-10-14
[6]Regulation (EC) No 1272/2008 of the European Parliament and of the Council · EU reuse policy, CC BY 4.0 · via PubChem · retrieved 2026-10-14
[7]European Chemicals Agency (ECHA) · ECHA legal notice: reuse with acknowledgement · via PubChem · retrieved 2026-10-14
[8]Emergency Response Guidebook (ERG) · Public domain (US DOT) · via PubChem · retrieved 2026-10-14
[9]NMRShiftDB · Linked only · via PubChem · retrieved 2026-10-14
[10]SpectraBase · Linked only · via PubChem · retrieved 2026-10-14
[11]Human Metabolome Database (HMDB) · Linked only · via PubChem · retrieved 2026-10-14
[12]MassBank of North America (MoNA) · CC BY 4.0 · via PubChem · retrieved 2026-10-14
[13]NIST Mass Spectrometry Data Center · Linked only · via PubChem · retrieved 2026-10-14
[14]MassBank Europe · Linked only · via PubChem · retrieved 2026-10-14
·Calculated values: computed by Athanor with RDKit 2026.09 from the structure.
·Literature on PubChem

Data last updated 2026-10-14.