Sample drug model for Alzheimer's
Template · uploaded by @arbastro · October 25, 2026
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A sample, hypothetical DUB-based protein clearance concept for Alzheimer's. Use as a template for other drug models.
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@arbastro · October 25, 2026
Note: the mechanism is a bit oversimplified. DUBs don't necessarily promote protein clearance; removing ubiquitin chains can actually prevent degradation. Tau and amyloid-beta also require different clearance approaches, since tau is primarily intracellular while Aβ plaques are extracellular. The cysteine protease reaction at the bottom is a reasonable simplified model, but it doesn't directly demonstrate the proposed mechanism. I'd need to identify a specific DUB target and show how manipulating it would actually enhance clearance.